Identifying flaws in the GWAS datasets of a published Mendelian randomization study: complementary re-evaluation and suggestion for analytical refinements

• Published in: Journal of translational medicine Vol. 22; no. 1; pp. 311 - 6
• Main Authors: Xiang, Jia-Cheng, Xiong, Yi-Fan, Wang, Shao-Gang, Xia, Qi-Dong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 26.03.2024; BioMed Central; BMC
• Subjects: Alzheimer's disease; Cancer; Datasets; Family medical history; Gene loci; Genome-Wide Association Study; Hypotheses; Letter to the Editor; Localization; Medical screening; Mendelian Randomization Analysis

Within both gene regions, we discovered a very high posterior probability (100% and 99.14%) supporting Hypothesis 4 (H4), and two co-localized genetic loci (rs117310449 and rs6979218) were identified respectively (Fig. 2B, C, Table 1). SEE PDF] Additionally, the authors extracted eQTL data of brain...