Identifying flaws in the GWAS datasets of a published Mendelian randomization study: complementary re-evaluation and suggestion for analytical refinements

Within both gene regions, we discovered a very high posterior probability (100% and 99.14%) supporting Hypothesis 4 (H4), and two co-localized genetic loci (rs117310449 and rs6979218) were identified respectively (Fig. 2B, C, Table 1). SEE PDF] Additionally, the authors extracted eQTL data of brain...

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Published inJournal of translational medicine Vol. 22; no. 1; pp. 311 - 6
Main Authors Xiang, Jia-Cheng, Xiong, Yi-Fan, Wang, Shao-Gang, Xia, Qi-Dong
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 26.03.2024
BioMed Central
BMC
Subjects
Alzheimer's disease
Cancer
Datasets
Family medical history
Gene loci
Genome-Wide Association Study
Hypotheses
Letter to the Editor
Localization
Medical screening
Mendelian Randomization Analysis
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Summary:Within both gene regions, we discovered a very high posterior probability (100% and 99.14%) supporting Hypothesis 4 (H4), and two co-localized genetic loci (rs117310449 and rs6979218) were identified respectively (Fig. 2B, C, Table 1). SEE PDF] Additionally, the authors extracted eQTL data of brain tissue and whole blood from the GTEX database and identified PVRIG as a risk gene for AD by co-localization analysis. [...]collecting the cis-eQTLs near the PVRIG gene from the eQTLGen database as the exposure (instrumental variables demonstrated in Additional file 4:
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ObjectType-Correspondence-1
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ISSN:1479-5876
1479-5876
DOI:10.1186/s12967-024-05106-w