New Insights in the Biology of BDNF Synthesis and Release: Implications in CNS Function

BDNF has pleiotropic effects on neuronal development and synaptic plasticity that underlie circuit formation and cognitive function. Recent breakthroughs reveal that neuronal activity regulates BDNF cell biology, including Bdnf transcription, dendritic targeting and trafficking of BDNF mRNA and prot...

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Published inThe Journal of neuroscience Vol. 29; no. 41; pp. 12764 - 12767
Main Authors Greenberg, Michael E, Xu, Baoji, Lu, Bai, Hempstead, Barbara L
Format Journal Article
LanguageEnglish
Published United States Soc Neuroscience 14.10.2009
Society for Neuroscience
SeriesSymposium
Subjects
Animals
Brain-Derived Neurotrophic Factor - genetics
Brain-Derived Neurotrophic Factor - metabolism
Central Nervous System - physiology
Gene Expression Regulation - physiology
Neuronal Plasticity - genetics
Neuronal Plasticity - physiology
Neurons - cytology
Neurons - physiology
Protein Transport - physiology
Symposia and Mini-Symposia
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Summary:BDNF has pleiotropic effects on neuronal development and synaptic plasticity that underlie circuit formation and cognitive function. Recent breakthroughs reveal that neuronal activity regulates BDNF cell biology, including Bdnf transcription, dendritic targeting and trafficking of BDNF mRNA and protein, and secretion and extracellular conversion of proBDNF to mature BDNF. Defects in these mechanisms contribute differentially to cognitive dysfunction and anxiety-like behaviors. Here we review recent studies, presented at a symposium at Neuroscience 2009, that describe regulatory mechanisms that permit rapid and dynamic refinement of BDNF actions in neurons.
Bibliography:ObjectType-Article-1
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ISSN:0270-6474
1529-2401
DOI:10.1523/JNEUROSCI.3566-09.2009