Triacylglycerol Homeostasis: Insights from Yeast

• Published in: The Journal of biological chemistry Vol. 285; no. 21; pp. 15663 - 15667
• Main Author: Kohlwein, Sepp D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.05.2010; American Society for Biochemistry and Molecular Biology
• Subjects: Animals; Fatty Acid Metabolism; Homeostasis - physiology; Humans; Lipid Droplet; Lipid Metabolism Disorders - genetics; Lipid Metabolism Disorders - metabolism; Lipid Synthesis; Lipids; Lipotoxicity; Minireviews; Phospholipid Metabolism; Saccharomyces cerevisiae; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Triacylglycerol; Triglycerides - genetics; Triglycerides - metabolism; Yeast Metabolism; Triacylglycerol; Yeast Metabolism; Lipid Synthesis; Fatty Acid Metabolism; Lipid Droplet; Phospholipid Metabolism; Lipotoxicity; Saccharomyces cerevisiae
• ISSN: 0021-9258; 1083-351X
• DOI: 10.1074/jbc.R110.118356

The endemic increase in lipid-associated disorders such as obesity and type 2 diabetes mellitus has placed triacylglycerol metabolism and its associated organelle, lipid droplets, in the spotlight of biomedical research. Key enzymes of triacylglycerol metabolism are structurally and functionally conserved between yeast and mammalian cells, and studies in yeast have contributed significantly to the understanding of their biological function(s). Based on these similarities, studies performed in yeast may provide further significant mechanistic insight into the molecular basis of triacylglycerol homeostasis and its important physiological roles in healthy and diseased cells.