Current use of autologous adipose tissue-derived stromal vascular fraction cells for orthopedic applications

• Published in: Journal of biomedical science Vol. 24; no. 1; p. 9
• Main Authors: Pak, Jaewoo, Lee, Jung Hun, Park, Kwang Seung, Park, Moonhee, Kang, Lin-Woo, Lee, Sang Hee
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 31.01.2017; BioMed Central
• Subjects: Adipose Tissue - transplantation; Adipose tissues; Animals; Autografts; Body fat; Bone Diseases - therapy; Cartilage - metabolism; Cartilage - pathology; Cartilage Diseases - therapy; Health aspects; Humans; Review; Stem cells; Stromal Cells - transplantation; Tendon Injuries - therapy; Tendons - metabolism; Tendons - pathology; Mesenchymal stem cell; Effectiveness and safety; Stromal vascular fraction; Autologous adipose tissue-derived stem cells; Orthopedic applications
• ISSN: 1423-0127; 1021-7770; 1423-0127
• DOI: 10.1186/s12929-017-0318-z

Autologous adipose stromal vascular fractions (SVFs) containing adipose tissue-derived stem cells (ASCs) are currently being used in clinical settings for various orthopedic applications for human patients. Due to its potential capability of regenerating cartilage, bone, and tendons, autologous adipose SVFs are being tried in treating patients with osteoarthritis (OA), chondromalacia, meniscus tear, osteonecrosis of the femoral head, and tendon injuries. Here, we have reviewed available human clinical studies with regard to patient applications of autologous adipose SVF containing ASCs, specifically assessing effectiveness and safety in the field of orthopedic disorders. All studies reviewed in this article presents potential benefits of autologous adipose SVF in various orthopedic applications without any serious side effects.