Intrinsic cooperativity potentiates parallel cis -regulatory evolution

• Published in: eLife Vol. 7
• Main Authors: Sorrells, Trevor R, Johnson, Amanda N, Howard, Conor J, Britton, Candace S, Fowler, Kyle R, Feigerle, Jordan T, Weil, P Anthony, Johnson, Alexander D
• Format: Journal Article
• Language: English
• Published: England eLife Science Publications, Ltd 10.09.2018; eLife Sciences Publications Ltd; eLife Sciences Publications, Ltd
• Subjects: Base sequence; BASIC BIOLOGICAL SCIENCES; Binding sites; Biophysics; Butterflies; Chromosomes and Gene Expression; Convergent evolution; Cooperativity; DNA; DNA binding; DNA sequencing; DNA-Binding Proteins - genetics; Drug resistance; ENVIRONMENTAL SCIENCES; Evolution; Evolution (Biology); Evolutionary Biology; Experiments; Fungal Proteins - genetics; Fungi; Gene expression; Gene Expression Regulation, Fungal; Genes; Genetic regulation; Genetic research; Genomes; Genomics; Kluyveromyces lactis; Life Sciences & Biomedicine - Other Topics; Minichromosome Maintenance 1 Protein - genetics; Mutation; Pathogenic microorganisms; Protein binding; Proteins; Rap1 protein; Regulatory Elements, Transcriptional - genetics; Regulatory proteins; Regulatory sequences; Ribosomal proteins; Ribosomal Proteins - genetics; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae Proteins - genetics; Stock prices; Telomere-Binding Proteins - genetics; TFIID protein; Transcription (Genetics); Transcription activation; transcription factors; Transcription Factors - genetics; United States > US; San Francisco California; California; evolutionary biology; transcription factors; chromosomes; Kluyveromyces lactis; evolution; gene expression; S. cerevisiae

Convergent evolutionary events in independent lineages provide an opportunity to understand why evolution favors certain outcomes over others. We studied such a case where a large set of genes-those coding for the ribosomal proteins-gained -regulatory sequences for a particular transcription regulat...