Determining promoter location based on DNA structure first-principles calculations

A new method for the prediction of promoter regions based on atomic molecular dynamics simulations of small oligonucleotides has been developed. The method works independently of gene structure conservation and orthology and of the presence of detectable sequence features. Results obtained with our...

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Bibliographic Details
Published inGenome biology Vol. 8; no. 12; p. R263
Main Authors Goñi, J Ramon, Pérez, Alberto, Torrents, David, Orozco, Modesto
Format Journal Article
LanguageEnglish
Published England BioMed Central 01.01.2007
Subjects
Algorithms
DNA - chemistry
DNA - genetics
Gene Expression
Humans
Method
Oligonucleotides - chemistry
Oligonucleotides - genetics
Promoter Regions, Genetic
Software
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Summary:A new method for the prediction of promoter regions based on atomic molecular dynamics simulations of small oligonucleotides has been developed. The method works independently of gene structure conservation and orthology and of the presence of detectable sequence features. Results obtained with our method confirm the existence of a hidden physical code that modulates genome expression.
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ISSN:1465-6906
1474-760X
1465-6914
DOI:10.1186/gb-2007-8-12-r263