Prevalence of hyperuricemia among type 2 diabetes mellitus patients in Africa: a systematic review and meta-analysis

• Published in: BMC endocrine disorders Vol. 23; no. 1; p. 153
• Main Authors: Alemayehu, Ermiyas, Fiseha, Temesgen, Bambo, Getachew Mesfin, Sahile Kebede, Samuel, Bisetegn, Habtye, Tilahun, Mihret, Debash, Habtu, Ebrahim, Hussen, Mohammed, Ousman, Belete, Melaku Ashagrie, Gedefie, Alemu
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 18.07.2023; BioMed Central; BMC
• Subjects: Africa; Analysis; Atherosclerosis; Cardiovascular disease; Cardiovascular diseases; Coronary artery disease; Coronary heart disease; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetic nephropathy; Diabetic neuropathies; Diabetic neuropathy; Diabetics; Health aspects; Heart diseases; Hyperuricemia; Insulin resistance; Meta-analysis; Morbidity; Mortality; Nephropathy; Nigeria; Prevalence; Prognosis; Public health; Qualitative research; Quality control; Retinopathy; Sensitivity analysis; Software; Statistical analysis; Systematic review; Type 2 diabetes; Uric acid; Nigeria; Africa; Type 2 diabetes; Systematic review; Hyperuricemia; Prevalence; Africa; Meta-analysis
• ISSN: 1472-6823; 1472-6823
• DOI: 10.1186/s12902-023-01408-0

Hyperuricemia increases morbidity and mortality in type 2 diabetic individuals. It is linked to the expansion of diabetes and cardiovascular diseases indicators, as well as being a significant predictor of coronary artery disease. It also leads to a poor prognosis and increment of diabetic complications including diabetic neuropathy, retinopathy, and nephropathy. Therefore, this systematic review and meta-analysis was aimed to determine the pooled prevalence of hyperuricemia among type 2 diabetes mellitus patients in Africa. We conducted a systematic review and meta-analysis following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. To identify relevant articles, we searched electronic databases such as PubMed, Google Scholar, African Journal Online, Science Direct, Embase, ResearchGate, Scopus, and Web of Sciences. The quality of the included studies was assessed using the Newcastle-Ottawa Quality Assessment Scale. Statistical analysis was performed using Stata 14.0 software. To evaluate heterogeneity, we utilized Cochran's Q test and I statistics. Publication bias was assessed through the examination of a funnel plot and Egger's test. The pooled prevalence was estimated using a random effect model. Furthermore, sub-group and sensitivity analyses were conducted. The overall pooled prevalence of hyperuricemia among type 2 diabetic patients in Africa was 27.28% (95% CI: 23.07, 31.49). The prevalence was highest in Central Africa 33.72% (95% CI: 23.49, 43.95), and lowest in North Africa 24.72% (95% CI: 14.38, 35.07). Regarding sex, the pooled prevalence of hyperuricemia among female and male type 2 diabetic patients was 28.02% (95% CI: 22.92, 33.48) and 28.20% (95% CI: 22.92, 33.48), respectively. This systematic review and meta-analysis showed a high prevalence of hyperuricemia among type 2 diabetic patients. So, regular screening and diagnosis of hyperuricemia required for preventing its pathological effects and contribution to chronic complications of diabetes. PROSPERO (2022: CRD42022331279).