Active surveillance of atypical cartilaginous tumours of bone: short term quality of life measurements

• Published in: Journal of orthopaedic surgery and research Vol. 18; no. 1; pp. 208 - 8
• Main Authors: Deckers, Claudia, van Zeijl, Nander T, van Hooff, Miranda L, Veldman-Goossen, Petra I, Schreuder, H W Bart, Dierselhuis, Edwin F, van der Geest, Ingrid C M
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.03.2023; BioMed Central; BMC
• Subjects: Asymptomatic; Bone cancer; Bone neoplasms; Bone tumors; Chondroma - pathology; Chondroma - surgery; Chondrosarcoma; Comparative analysis; Computer industry; Cryosurgery; Curettage; Decision making; Health aspects; Humans; Magnetic resonance imaging; Medical research; Medicine, Experimental; Orthopedics; Pain; Patients; Prospective Studies; Quality of life; Quality of Life - psychology; Questionnaires; Surgery; Surveillance; Surveys; Tumors; Watchful Waiting; United States; Netherlands; Chondrosarcoma; Watchful waiting; Bone neoplasms; Quality of life
• ISSN: 1749-799X; 1749-799X
• DOI: 10.1186/s13018-023-03694-9

In the recent years active surveillance has been introduced for atypical cartilaginous tumours (ACT). This is the first study on the impact of this new treatment approach on patients' quality-of-life. We evaluated general health-related quality of life (HRQL) in patients diagnosed with enchondroma or ACT. In this prospective study, patients recently diagnosed with enchondroma and ACT of the long bones were asked to participate. Health-related quality of life (HRQL) was assessed at diagnosis and at six month follow-up, using the 36-item Short Form Health Survey (SF-36) and Numeric Pain Rating Scale (NRS). HRQL of the active surveillance group was compared to the Dutch population and a Dutch sample with locoregional cancer. In total, 45 patients were included in the study, of which four patients underwent curettage and cryosurgery, 41 patients were under active surveillance. The HRQL of the active surveillance group seemed lower compared to the Dutch population, but similar to patients suffering locoregional cancers. No comparison between the surgery and the active surveillance group could be made. In the active surveillance group no statistical difference was found between baseline and six months follow-up regarding HRQL and pain during rest and activities. Patients diagnosed with non-malignant chondroid tumours have lower HRQL compared to the healthy population. Active surveillance had no adverse effect on patients well-being, after six months active surveillance the HRQL remained unchanged. Interestingly, in our study no impact on mental health was seen, implicating that diagnosed but untreated chondroid tumours do not seem to influence patients anxiety.