Neural HO-1/sterol interactions in vivo : Implications for Alzheimer’s disease

• Published in: Neuroscience Vol. 280; pp. 40 - 49
• Main Authors: Hascalovici, J.R, Song, W, Liberman, A, Vaya, J, Khatib, S, Holcroft, C, Laferla, F, Schipper, H.M
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 07.11.2014; Elsevier
• Subjects: Adult and adolescent clinical studies; Aging - metabolism; Alzheimer Disease - metabolism; Alzheimer’s disease; Amyloid beta-Protein Precursor - genetics; Amyloid beta-Protein Precursor - metabolism; Animals; astrocyte; Astrocytes - drug effects; Astrocytes - metabolism; Biological and medical sciences; Brain - metabolism; cholesterol; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Glial Fibrillary Acidic Protein; HEK293 Cells; heme oxygenase-1; Heme Oxygenase-1 - genetics; Heme Oxygenase-1 - metabolism; Homeostasis; Humans; lipid; Medical sciences; Membrane Proteins - metabolism; Mice, Transgenic; Mutation; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Neurology; Organic mental disorders. Neuropsychology; Oxidation-Reduction; oxysterol; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Rats; Sterols - metabolism; APP; oxysterol; 4β-OH; TRE; LXR; 7α-hydroxycholesterol; Hmox1; HO-1; phosphate-buffered saline; 7keto-CH; lipid; Aβ; 7β-hydroxycholesterol; cytomegalovirus; amyloid precursor protein; 7-ketocholesterol; 7α-OH; cholesterol; 4β-hydroxycholesterol; 24-OH; astrocyte; polymerase chain reaction; β-amyloid; PBS; GC–MS; AD; Alzheimer’s disease; CH; human HO-1 gene; Alzheimer-disease; carbon monoxide; 3xTg-AD; heme oxygenase-1; CO; CMV; GFAP; liver-X receptor; gas chromatography–mass spectrometry; triple transgenic AD mouse; 24-hydroxycholesterol; tetracycline response element; glial fibrillary acidic protein; 7β-OH; PCR; Nervous system diseases; Enzyme; Alzheimer disease; Neuroglia; Heme oxygenase (decyclizing); Lipids; Astrocyte; Cholesterol; Cerebral disorder; Central nervous system disease; Degenerative disease; Oxidoreductases; Alzheimer's disease; Sterol
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2014.09.001

Highlights • We employ two transgenic mouse models to examine sterol neurochemistry related to AD. • The effects of heme oxygenase-1 (HO-1) expression on sterol homeostasis are described. • Differential effects of HO-1 on brain sterols are contingent on the redox microenvironment. • Data provide insight into sterol homeostasis in CNS aging and degeneration.