Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway

• Published in: Toxicology (Amsterdam) Vol. 303; no. 7; pp. 107 - 114
• Main Authors: Shi, Haitao, Dong, Lei, Jiang, Jiong, Zhao, Juhui, Zhao, Gang, Dang, Xiaoyan, Lu, Xiaolan, Jia, Miao
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 07.01.2013
• Subjects: actin; Animals; antioxidant activity; blood serum; bone morphogenetic proteins; carbon tetrachloride; Carbon Tetrachloride - toxicity; Chlorogenic acid; Chlorogenic Acid - pharmacology; collagen; Cytokines - metabolism; Emergency; Enzyme-Linked Immunosorbent Assay; fibrosis; gene expression; Gene Expression Regulation - drug effects; histopathology; inducible nitric oxide synthase; inflammation; Inflammation - immunology; Inflammation - prevention & control; interleukin-1beta; interleukin-6; liver; Liver - drug effects; Liver - pathology; liver cirrhosis; Liver Cirrhosis - pathology; Liver Cirrhosis - prevention & control; Liver fibrosis; Liver inflammation; Male; messenger RNA; muscles; Myeloid Differentiation Factor 88 - metabolism; NF-kappa B - metabolism; prostaglandin synthase; protective effect; protein synthesis; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - metabolism; signal transduction; Signal Transduction - drug effects; TLR4; Toll-like receptor 4; Toll-Like Receptor 4 - metabolism; toxicology; transcription factor NF-kappa B; tumor necrosis factor-alpha; Western blotting; α-smooth muscle actin; COX-2; cyclooxygenase-2; Liver fibrosis; MyD88; LPS; interleukin-6; inducible nitric oxide synthase; interleukin-1β; α-SMA; NF-κB; myeloid differentiation factor 88; iNOS; CGA; hepatic stellate cells; lipopolysaccharides; Chlorogenic acid; carbon tetrachloride; IL-1β; Liver inflammation; IL-6; CCl 4; nuclear factor-κB; bone morphogenetic protein and activin membrane-bound inhibitor; TNF-α; tumor necrosis factor-α; HSCs; Bambi; TLR4; toll-like receptor 4; CCl4
• ISSN: 0300-483X; 1879-3185
• DOI: 10.1016/j.tox.2012.10.025

Highlights ► Chlorogenic acid decreased serum transaminase level and increased albumin level. ► Chlorogenic acid attenuated CCl4 -induced liver collagen deposition. ► Chlorogenic acid ameliorated CCl4 -induced inflammatory response. ► Chlorogenic acid inhibited the activation of TLR4/NF-κB signaling in liver.