Chemokines in CSF of Alzheimer's disease patients

Some studies have linked the presence of chemokines to the early stages of Alzheimer's disease (AD). Then, the identification of these mediators may contribute to diagnosis. Our objective was to evaluate the levels of beta-amyloid (BA), tau, phospho-tau (p-tau) and chemokines (CCL2, CXCL8 and C...

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Published inArquivos de neuro-psiquiatria Vol. 69; no. 3; pp. 455 - 459
Main Authors Corrêa, Jôice Dias, Starling, Daniela, Teixeira, Antônio Lúcio, Caramelli, Paulo, Silva, Tarcília Aparecida
Format Journal Article
LanguageEnglish
Published Brazil Academia Brasileira de Neurologia - ABNEURO 01.06.2011
Academia Brasileira de Neurologia (ABNEURO)
Subjects
Aged
Alzheimer Disease - cerebrospinal fluid
Alzheimer Disease - diagnosis
Amyloid beta-Peptides - cerebrospinal fluid
Biomarkers - cerebrospinal fluid
Chemokine CCL2 - cerebrospinal fluid
Chemokine CXCL10 - cerebrospinal fluid
Chemokines - cerebrospinal fluid
Disease Progression
doença de Alzheimer
Female
Humans
inflamação
Interleukin-8 - cerebrospinal fluid
líquido cefalorraquidiano
Male
Middle Aged
NEUROSCIENCES
Prospective Studies
PSYCHIATRY
quimiocinas
tau Proteins - cerebrospinal fluid
doença de Alzheimer
líquido cefalorraquidiano
inflammation
cerebrospinal fluid
inflamação
chemokines
quimiocinas
Alzheimer's disease
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Summary:Some studies have linked the presence of chemokines to the early stages of Alzheimer's disease (AD). Then, the identification of these mediators may contribute to diagnosis. Our objective was to evaluate the levels of beta-amyloid (BA), tau, phospho-tau (p-tau) and chemokines (CCL2, CXCL8 and CXCL10) in the cerebrospinal fluid (CSF) of patients with AD and healthy controls. The correlation of these markers with clinical parameters was also evaluated. The levels of p-tau were higher in AD compared to controls, while the tau/p-tau ratio was decreased. The expression of CCL2 was increased in AD. A positive correlation was observed between BA levels and all chemokines studied, and between CCL2 and p-tau levels. Our results suggest that levels of CCL2 in CSF are involved in the pathogenesis of AD and it may be an additional useful biomarker for monitoring disease progression.
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ISSN:0004-282X
1678-4227
1678-4227
0004-282X
DOI:10.1590/s0004-282x2011000400009