The interplay of resting and inhibitory control‐related theta‐band activity depends on age

• Published in: Human brain mapping Vol. 42; no. 12; pp. 3845 - 3857
• Main Authors: Pscherer, Charlotte, Bluschke, Annet, Mückschel, Moritz, Beste, Christian
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 15.08.2021
• Subjects: Adolescent; Adult; Adults; Age; Age Factors; Animal behavior; Beamforming; Child; Cognitive ability; cognitive control; EEG; Electrodes; Electroencephalography - methods; Female; Human Development - physiology; Humans; Hypotheses; Information processing; Inhibition; Inhibition (psychology); Inhibition, Psychological; Male; Neurophysiology; Prefrontal Cortex - physiology; Psychomotor Performance - physiology; response inhibition; resting‐state activity; Signal processing; Teenagers; theta power; Theta Rhythm - physiology; Young Adult; cognitive control; resting-state activity; theta power; age; response inhibition
• ISSN: 1065-9471; 1097-0193; 1097-0193
• DOI: 10.1002/hbm.25469

Resting‐state neural activity plays an important role for cognitive control processes. Regarding response inhibition processes, an important facet of cognitive control, especially theta‐band activity has been the focus of research. Theoretical considerations suggest that the interrelation of resting and task‐related theta activity is subject to maturational effects. To investigate whether the relationship between resting theta activity and task‐related theta activity during a response inhibition task changes even in young age, we tested N = 166 healthy participants between 8 and 30 years of age. We found significant correlations between resting and inhibitory control‐related theta activity as well as behavioral inhibition performance. Importantly, these correlations were moderated by age. The moderation analysis revealed that higher resting theta activity was associated with stronger inhibition‐related theta activity in individuals above the age of ~10.7 years. The EEG beamforming analysis showed that this activity is associated with superior frontal region function (BA6). The correlation between resting and superior frontal response inhibition‐related theta activity became stronger with increasing age. A similar pattern was found for response inhibition performance, albeit only evident from the age of ~19.5 years. The results suggest that with increasing age, resting theta activity becomes increasingly important for processing the alarm/surprise signals in superior frontal brain regions during inhibitory control. Possible causes for these developmental changes are discussed. Resting‐state neural activity plays an important role in cognitive control processes. Theoretical considerations suggest that the interrelation of resting and task‐related theta activity is subject to maturational effects. We show that with increasing age, resting theta activity becomes increasingly important for response inhibition processes in superior frontal brain regions.