Tumor Induction in Monkeys after Administration of Dimethylhydrazine

• Published in: Cancer science Vol. 83; no. 6; pp. 584 - 587
• Main Authors: Beniashvili, Dzhemal Sh, Turusov, Vladimir S., Krutovskikh, Vladimir A., Sartania, Mtvarisa S.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.1992; Japanese Cancer Association; John Wiley & Sons, Inc
• Subjects: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenocarcinoma - chemically induced; Adenocarcinoma - pathology; Animals; Biological and medical sciences; Body weight; Carcinogenesis, carcinogens and anticarcinogens; Chemical agents; Colon cancer; Colon tumor; Colonic Neoplasms - chemically induced; Colonic Neoplasms - pathology; Dimethylhydrazines - administration & dosage; Dose-Response Relationship, Drug; Female; Key words; Macaca fascicularis; Male; Medical sciences; Monkey; Myoma - chemically induced; Myoma - pathology; Neoplasms, Experimental - chemically induced; Tumors; Uterine Neoplasms - chemically induced; Uterine Neoplasms - pathology; Uterus; Uterus tumor; Adenocarcinoma; Leiomyoma; Monkey; Malignant tumor; Carcinogenesis; Female genital diseases; Vertebrata; Experimental disease; Mammalia; Uterus; Animal; Primates; Uterine diseases; Digestive diseases; Intestinal disease; Benign neoplasm; Colon
• ISSN: 0910-5050; 1347-9032; 1349-7006; 1876-4673
• DOI: 10.1111/j.1349-7006.1992.tb00129.x

1,2‐Dimethylhydrazine (DMH) was administered subcutaneously to nine Macaca fascicularis monkeys (6 males and 3 females) at doses of 16 mg/kg body weight, three times a month for two years. Colon cancer was detected in two male monkeys after total DMH doses of 1080 and 3696 mg (528 and 400 mg/kg body wt., respectively). A uterine tumor was induced in one female monkey which received 3648 mg of DMH (608 mg/kg body wt.). Latent periods of tumor development were 34, 47 and 55 weeks, respectively. Histologically, the colon tumors had the structure of adenocarcinoma in both cases and the uterine tumor was diagnosed as flbromyoma.