多项式拟合法设定辐照灭菌剂量的研究

受传统方法精确度的限制,生产实践中辐照灭菌剂量的设定值往往超过产品的实际需要。多余的辐照剂量会对产品造成不必要的辐照损伤,同时也降低了辐照工厂的产能。本文通过理论研究证明,任一给定抗性分布的微生物种群存在一条非线性的＂灭菌剂量曲线＂。对于具有标准抗性分布（Standard distribution of resistances,SDR）的微生物种群,采用5种常用函数拟合其灭菌剂量曲线的结果表明,5次多项式函数的拟合程度最好。与传统使用线性函数拟合的方法相比,基于5次多项式函数拟合的灭菌剂量设定方法可以将所设定的灭菌剂量与理论值的偏差范围从-9．8％-123．1％缩小至-7．7％-1．9％。此方...

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Bibliographic Details
Published in核技术 Vol. 37; no. 11; pp. 17 - 22
Main Author 龚频 汤晓斌 陈达
Format Journal Article
LanguageChinese
Published 南京航空航天大学核科学与工程系 南京210016 2014
Subjects
多项式拟合
标准抗性分布
灭菌剂量设定
辐照灭菌
标准抗性分布
Polynomial fitting
Standard distribution of resistances (SDR)
多项式拟合
灭菌剂量设定
辐照灭菌
Radiation sterilization
Sterilization dose setting
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ISSN0253-3219
DOI10.11889/j.0253-3219.2014.hjs.37.110202

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Summary:受传统方法精确度的限制,生产实践中辐照灭菌剂量的设定值往往超过产品的实际需要。多余的辐照剂量会对产品造成不必要的辐照损伤,同时也降低了辐照工厂的产能。本文通过理论研究证明,任一给定抗性分布的微生物种群存在一条非线性的＂灭菌剂量曲线＂。对于具有标准抗性分布（Standard distribution of resistances,SDR）的微生物种群,采用5种常用函数拟合其灭菌剂量曲线的结果表明,5次多项式函数的拟合程度最好。与传统使用线性函数拟合的方法相比,基于5次多项式函数拟合的灭菌剂量设定方法可以将所设定的灭菌剂量与理论值的偏差范围从-9．8％-123．1％缩小至-7．7％-1．9％。此方法可以在保证产品灭菌合格的基础上有效降低多余的辐照剂量。
Bibliography:GONG Pin TANG Xiaobin CHEN Da （Department of Nuclear Science and Engineering, Nanjing University of Aeronautics ＆ Astronautics, Nanjing 210016, China）
31-1342/TL
Polynomial fitting, Radiation sterilization, Standard distribution of resistances （SDR）, Sterilization dose setting
Background： The setting of sterilization dose in practice is usually higher than the actual need of product due to the accuracy limit of traditional methods. Extra irradiation dose leads to unnecessary radiation damage to products and reduces the production capacity of irradiation plants. So it is important to find a more accurate method to set the sterilization dose for micropopulation. Purpose： This research is to find a new approach to set the sterilization dose more accurately for micropopulation of products. Methods： First of all, the relationship between the survival bacteria count and radiation dose through theoretical derivation is studied. Then, the data of sterilization dose curve of micropopulation is calculated according to the
ISSN:0253-3219
DOI:10.11889/j.0253-3219.2014.hjs.37.110202