18F和^11C标记的氨基酸类分子探针的合成及应用研究进展
PET/CT显像作为一种诊断肿瘤、评价疗效和预后的有力工具得到了快速的发展。氨基酸类正电子药物被临床证明是可以弥补当前^18F-FDG PET/CT不足的重要药物,不像^18F-FDG,氨基酸类分子探针在正常脑组织中的摄取很低,在良性的病变如炎症、水肿、坏死和纤维化的组织几乎不摄取,可以提高PET/CT显像的特异性,其合成标记的研发日益得到重视。本文重点介绍了当前利用短半衰期正电子核素^18F和^11C标记合成正电子类氨基酸的方法学和初步应用研究的最新进展。...
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| Published in | 核技术 Vol. 37; no. 8; pp. 23 - 29 |
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| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
广东省人民医院(广东省医学科学院)广州510080%中山大学附属第一医院 广州510080
2014
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0253-3219 |
| DOI | 10.11889/j.0253-3219.2014.hjs.37.080302 |
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| Summary: | PET/CT显像作为一种诊断肿瘤、评价疗效和预后的有力工具得到了快速的发展。氨基酸类正电子药物被临床证明是可以弥补当前^18F-FDG PET/CT不足的重要药物,不像^18F-FDG,氨基酸类分子探针在正常脑组织中的摄取很低,在良性的病变如炎症、水肿、坏死和纤维化的组织几乎不摄取,可以提高PET/CT显像的特异性,其合成标记的研发日益得到重视。本文重点介绍了当前利用短半衰期正电子核素^18F和^11C标记合成正电子类氨基酸的方法学和初步应用研究的最新进展。 |
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| Bibliography: | 31-1342/TL Synthesis, Amino acid, Molecular probes, Positron emission tomography （PET） Background： Positron emission tomography （PET） is in rapidly developing as a powerful imaging technique for diagnosis, efficacy evaluation and prognosis of tumor. In contrast to ^18F-FDG, the amino acid tracers were helpful additional tools for differentiating tumor tissue and inflammation, edematous, necrotic and fibrotic tissue because of their low uptake in those tissues, so that amino acid tracers appear to be more specific than the widely used ^18F-FDG As a result, a number of attempts have been undertaken for radio-synthesis of amino acid with short half-life nuclide ^18F and ^11C. Purpose： The aim is to review and discuss the present knowledge on synthesis methods and preliminary clinic application of labeling amino acid. Methods： The advances on the synthesis methods and preliminary clinic application of labeling amino acid in recent years were introduced and discussed. Results： In recent years, many new ^18F or ^11-l |
| ISSN: | 0253-3219 |
| DOI: | 10.11889/j.0253-3219.2014.hjs.37.080302 |