The interplay between mitochondrial dynamics and mitophagy

Mitochondrial dynamics and mitophagy are recognized as two critical processes underlying mitochondrial homeostasis. Morphological and bioenergetic characterization of the life cycle of an individual mitochondrion reveals several points where fusion, fission, and mitophagy interact. Mitochondrial fis...

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Bibliographic Details
Published inAntioxidants & redox signaling Vol. 14; no. 10; p. 1939
Main Authors Twig, Gilad, Shirihai, Orian S
Format Journal Article
LanguageEnglish
Published United States 15.05.2011
Subjects
Animals
Autophagy - physiology
Humans
Membrane Fusion - physiology
Membrane Potential, Mitochondrial - physiology
Mitochondria - metabolism
Models, Biological
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Summary:Mitochondrial dynamics and mitophagy are recognized as two critical processes underlying mitochondrial homeostasis. Morphological and bioenergetic characterization of the life cycle of an individual mitochondrion reveals several points where fusion, fission, and mitophagy interact. Mitochondrial fission can produce an impaired daughter unit that will be targeted by the autophagic machinery. Mitochondrial fusion, on the other hand, may serve to dilute impaired respiratory components and thereby prevent their removal. The inverse dependency of fusion and mitophagy on membrane potential allows them to act as complementary rather than competitive fates of the daughter mitochondrion after a fission event. We discuss the interplay between mitochondrial dynamics and mitophagy in different tissues and in different disease models under both stress-induced and steady-state conditions.
ISSN:1557-7716
DOI:10.1089/ars.2010.3779