Inflammasome inhibitors: promising therapeutic approaches against cancer

Inflammation has long been accepted as a key component of carcinogenesis. During inflammation, inflammasomes are potent contributors to the activation of inflammatory cytokines that lead to an inflammatory cascade. Considering the contributing role of inflammasomes in cancer progression, inflammasom...

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Bibliographic Details
Published inJournal of hematology and oncology Vol. 12; no. 1; pp. 64 - 13
Main Authors Xu, Shengchao, Li, Xizhe, Liu, Yuanqi, Xia, Yu, Chang, Ruimin, Zhang, Chunfang
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 26.06.2019
BioMed Central
BMC
Subjects
Antimitotic agents
Antineoplastic agents
Cancer
Care and treatment
Inflammasome inhibitors
Review
Therapeutics
China
Inflammasome inhibitors
Therapeutics
Cancer
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Summary:Inflammation has long been accepted as a key component of carcinogenesis. During inflammation, inflammasomes are potent contributors to the activation of inflammatory cytokines that lead to an inflammatory cascade. Considering the contributing role of inflammasomes in cancer progression, inflammasome inhibitors seem to have a promising future in cancer treatment and prevention. Here, we summarize the structures and signaling pathways of inflammasomes and detail some inflammasome inhibitors used to treat various forms of cancer, which we expect to be used in novel anticancer approaches. However, the practical application of inflammasome inhibitors is limited in regard to specific types of cancer, and the associated clinical trials have not yet been completed. Therefore, additional studies are required to explore more innovative and effective medicines for future clinical treatment of cancer.
ISSN:1756-8722
1756-8722
DOI:10.1186/s13045-019-0755-0