Effect of acupuncture therapy combined with fluticasone propionate in the treatment of persistent allergic rhinitis: study protocol for a randomized controlled trial

• Published in: Current controlled trials in cardiovascular medicine Vol. 23; no. 1; p. 94
• Main Authors: Fan, Qi, Feng, Yixuan, Hou, Yan, Wu, Feihu, Zhang, Wei, Nie, Wenbin, Li, Bin, Zhou, Zhongyu, Fu, Wenbin, Shi, Lei, Sun, Zhongren, Zhao, Hong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 31.01.2022; BioMed Central; BMC
• Subjects: Acupuncture; Acupuncture therapy; Acupuncture Therapy - adverse effects; Androstadienes - adverse effects; Care and treatment; Chinese medicine; Clinical trials; Diagnosis; Dosage and administration; Fluticasone; Fluticasone - adverse effects; Hay fever; Histamine; Humans; Informed consent; Medical research; Multicenter Studies as Topic; Nose; Patients; Persistent allergic rhinitis; Quality of Life; Randomized controlled trial; Randomized Controlled Trials as Topic; Rhinitis; Rhinitis, Allergic - diagnosis; Rhinitis, Allergic - therapy; Single-Blind Method; Sinusitis; Steroids; Study Protocol; Teaching hospitals; Testing; Treatment Outcome; China; Beijing China; Persistent allergic rhinitis; Study protocol; Acupuncture therapy; Randomized controlled trial
• ISSN: 1745-6215; 1745-6215
• DOI: 10.1186/s13063-022-06020-6

Allergic rhinitis (AR) is an immunoglobulin E (IgE)-mediated inflammatory response. Persistent allergic rhinitis (PAR) is a subtype of AR, but the treatment of PAR is still a problem. Acupuncture is used as an alternative therapy for AR in clinical practice. The aim of this study is to evaluate the effectiveness of acupuncture therapy combined with fluticasone propionate nasal spray in comparison to fluticasone propionate nasal spray alone in the relief of symptoms for PAR. This study is a multicenter, single-blind, randomized controlled trial. A total of 260 eligible patients will be randomly assigned into the treatment group or the control group. The treatment group will receive the nasal fluticasone propionate combined with acupuncture, and the control group will receive fluticasone propionate nasal spray alone for 6 weeks. The primary outcome is the change in the Reflective Total Nasal Symptom Score (rTNSS) from baseline to the end of treatment, and the Total Non Nasal Symptom Score (TNNSS), reflective total ocular symptom score (rTOSS), Rhinitis Quality of Life Questionnaire (RQLQ), use of antiallergic drugs, and the Rhinitis Control Assessment Test (RCAT) are used as secondary outcomes. The participants will be followed up for another 24 weeks after treatment. This clinical trial will be able to provide high level evidence on the acupuncture therapy combined with fluticasone propionate nasal spray in the treatment of PAR. ISRCTN Registry, ID: ISRCTN44040506 . Registered on 22 July 2020.