Dyslipidemia and cardiovascular disease risk among the MASHAD study population

• Published in: Lipids in health and disease Vol. 19; no. 1; p. 42
• Main Authors: Hedayatnia, Mahshad, Asadi, Zahra, Zare-Feyzabadi, Reza, Yaghooti-Khorasani, Mahdiyeh, Ghazizadeh, Hamideh, Ghaffarian-Zirak, Roshanak, Nosrati-Tirkani, Abolfazl, Mohammadi-Bajgiran, Maryam, Rohban, Mohadese, Sadabadi, Fatemeh, Rahimi, Hamid-Reza, Ghalandari, Marzieh, Ghaffari, Mohammad-Seddigh, Yousefi, Asa, Pouresmaeili, Elnaz, Besharatlou, Mohammad-Reza, Moohebati, Mohsen, Ferns, Gordon A, Esmaily, Habibollah, Ghayour-Mobarhan, Majid
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.03.2020; BioMed Central; BMC
• Subjects: Angina pectoris; Anticholesteremic agents; Antihypertensives; Blood pressure; Body mass index; Cardiovascular disease; Cardiovascular diseases; Cholesterol; Diabetes mellitus; Diet; Diseases; Dyslipidemia; Dyslipidemias; Energy consumption; Food; Health care; Health risk assessment; Heart attack; Heart attacks; Hypertension; Lipids; Lipoproteins; Low density lipoproteins; Medical imaging; Medical research; Metabolic disorders; Mortality; Myocardial infarction; Population; Population studies; Proteins; Questionnaires; Risk factors; Stable angina; Statistics; Studies; Total cholesterol; Triglycerides; Unstable angina; Women; Iran; Myocardial infarction; Cardiovascular disease; Total cholesterol; Unstable angina; Dyslipidemia; Stable angina
• ISSN: 1476-511X; 1476-511X
• DOI: 10.1186/s12944-020-01204-y

Dyslipidemia may be defined as increased levels of serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), or a decreased serum high-density lipoprotein cholesterol (HDL-C) concentration. Dyslipidemia is an established risk factor for cardiovascular disease (CVD). We aimed to investigate the association of dyslipidemia and CVD events among a population sample from Mashhad, in northeastern Iran. This prospective cohort study comprised a population of 8698 men and women aged 35-65 years who were recruited from the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) study. Socioeconomic and demographic status, anthropometric parameters, laboratory evaluations, lifestyle factors, and medical history were gathered through a comprehensive questionnaire and laboratory and clinical assessment for all participants. Cox regression model and 95% confidence interval (CI) were used to evaluate the association of dyslipidemia and its components with CVD incidence. After 6 years of follow-up, 233 cases of CVD (including 119 cases of unstable angina [US], 74 cases of stable angina [SA], and 40 cases of myocardial infarction [MI]) were identified in the study population. Unadjusted baseline serum LDL-C, TC, and TG levels were positively associated with the risk of total CVD events among the entire population (HR: 1.54, 95% CI: 1.19-2; P-value< 0.01; HR: 1.53; 95% CI: 1.18-1.98; P < 0.01; HR: 1.57; 95% CI: 1.27-2.03; P < 0.01, respectively). However, after adjusting for confounding factors (age, body mass index [BMI], family history of CVD, smoking status [non-smoker, ex-smoker and current smoker], lipid lowering drug treatment, anti-hypertensive drug treatment, hypertension, healthy eating index [HEI], total energy intake, and presence of diabetes mellitus), a significant direct association only remained between TC and MI risk in men (HR: 2.71; 95%CI: 1.12-6.57; P-value< 0.05). In the present study, TC baseline level was significantly associated with the risk of MI among men.