Sensitive marker for evaluation of hypertensive heart disease: extracellular volume and myocardial strain

• Published in: BMC cardiovascular disorders Vol. 20; no. 1; p. 292
• Main Authors: Niu, Junqiao, Zeng, Mu, Wang, Yan, Liu, Jun, Li, Hui, Wang, Shanshan, Zhou, Xiaoyue, Wang, Jia, Li, Yanyu, Hou, Feng, Zhu, Junwen
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 15.06.2020; BioMed Central; BMC
• Subjects: Adult; Antihypertensive Agents - therapeutic use; Antihypertensives; Biological markers; Blood pressure; Blood Pressure - drug effects; Cardiac function; Cardiomyocytes; Cardiovascular disease; CMR; Coronary artery disease; Diagnosis; Drugs; ECV; Female; Fibrosis; Health aspects; Heart diseases; Heart failure; HHD; Humans; Hypertension; Hypertension - complications; Hypertension - diagnosis; Hypertension - drug therapy; Hypertension - physiopathology; Hypertrophy; Hypertrophy, Left Ventricular - diagnostic imaging; Hypertrophy, Left Ventricular - etiology; Hypertrophy, Left Ventricular - physiopathology; Magnetic Resonance Imaging, Cine; Male; Middle Aged; Myocardial diseases; Myocardial strain; Myocardium; Myocardium - pathology; Patients; Predictive Value of Tests; Sensitivity analysis; Software; Statistical analysis; Studies; Systole; Time Factors; Treatment Outcome; Variance analysis; Ventricle; Ventricular Dysfunction, Left - diagnostic imaging; Ventricular Dysfunction, Left - etiology; Ventricular Dysfunction, Left - physiopathology; Ventricular Function, Left; Ventricular Remodeling; China; CMR; ECV; HHD; Myocardial strain
• ISSN: 1471-2261; 1471-2261
• DOI: 10.1186/s12872-020-01553-7

Evaluation of tissue fibrosis and myocardial hypertrophy in left ventricular (LV) remodeling is the basis of post-treatment evaluation of hypertensive heart disease (HHD). Extracellular volume (ECV) and myocardial strain parameters can indirectly reflect the changes of both. Our objective was to analyze the characteristics of ECV and strain parameters in LV myocardium of HHD with varying degrees of systolic dysfunction, and to explore the changes of both after treatment for hypertension. A total of 62 HHD patients were divided into 3 groups according to ejection fraction (EF < 30, 30%≦EF < 50%, EF≧50%). Twenty-one of these patients underwent cardiac magnetic resonance (CMR) reexamination more than six months after receiving antihypertensive medication. The initial T1 time and post-enhancement T1 time of each segment were measured, and the ECV was calculated. Radial strain (RS), circumferential strain (CS) and longitudinal strain (LS) of LV were measured by cvi42 software, and the differences in CMR parameters between different groups and before and after treatment were compared. ①The mean, basal and middle ECV value of HHD groups with different EF were all higher than that of the control group (P < 0.05), but the difference between HHD groups was not statistically significant. ②With the decrease of EF, the absolute value of both the global or local strain decreased. Strain is related to LVMI and ECV. ③In general, ECV, global RS (GRS) and global CS (GCS) improved after treatment, but the improvement of LS impairment in HHD patients is difficult. ECV and myocardial strain parameters are more sensitive to myocardial abnormalities, and ECV, GRS and GCS are more sensitive to treatment. However it is difficult to improve longitudinal strain impairment in HHD patients. ECV and myocardial strain parameters can be used as good makers for long-term monitoring of the efficacy of HHD patients.