Incidence and risk factors of micronutrient deficiency in patients with IBD and intestinal Behçet's disease: folate, vitamin B12, 25-OH-vitamin D, and ferritin

• Published in: BMC gastroenterology Vol. 21; no. 1; p. 32
• Main Authors: Park, Yong Eun, Park, Soo Jung, Park, Jae Jun, Cheon, Jae Hee, Kim, TaeIl, Kim, Won Ho
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 21.01.2021; BioMed Central; BMC
• Subjects: Acids; Age; Anemia; Anorexia; Behcet Syndrome - complications; Behcet Syndrome - epidemiology; Bone density; Complications and side effects; Crohn's disease; Deficiency diseases; Diarrhea; Dietary intake; Dietary minerals; Disease; Ferritin; Ferritins; Folic Acid; Gastroenterology; Humans; Incidence; Inflammatory bowel disease; Inflammatory bowel diseases; Inflammatory Bowel Diseases - complications; Inflammatory Bowel Diseases - epidemiology; Intestinal behçet’s disease; Intestine; Iron; Laboratories; Malnutrition; Micronutrients; Multivariate analysis; Patients; Quality of life; Retrospective Studies; Risk Factors; Salicylic acid; Statistics; Surgery; Trace elements; Variables; Vein & artery diseases; Vitamin B; Vitamin B 12; Vitamin B12; Vitamin D; Vitamin D Deficiency - epidemiology; Vitamin deficiency; South Korea; Inflammatory bowel disease; Micronutrients; Intestinal behçet’s disease; Risk factors
• ISSN: 1471-230X; 1471-230X
• DOI: 10.1186/s12876-021-01609-8

Patients with inflammatory bowel disease (IBD) and intestinal Behçet's disease (BD) are vulnerable to micronutrient deficiencies due to diarrhea-related gastrointestinal loss and poor dietary intake caused by disease-related anorexia. However, few studies have investigated the incidence and risk factors for micronutrient deficiency. We retrospectively analyzed 205 patients with IBD who underwent micronutrient examination, including folate, vitamin B12, 25-OH-vitamin D, and/or ferritin level quantification, with follow-up blood tests conducted 6 months later. Eighty patients (39.0%), who were deficient in any of the four micronutrients, were classified as the deficiency group, and the remaining 125 (61.0%) were classified as the non-deficient group. Compared to those in the non-deficiency group, patients in the deficiency group were much younger, had more Crohn's disease (CD) patients, more patients with a history of bowel operation, and significantly less 5-amino salicylic acid usage. Multivariate analysis revealed that CD and bowel operation were significant independent factors associated with micronutrient deficiency. The incidence of micronutrient deficiency was high (39.0%). Factors including CD, bowel operation, and younger ages were found to be associated with higher risks of deficiency. Therefore, patients with IBD, especially young patients with CD who have undergone bowel resection surgery, need more attention paid to micronutrition.