Myeloid-derived suppressor cells in hematological malignancies: friends or foes

Myeloid-derived suppressor cells (MDSCs) are newly identified immature myeloid cells that are characterized by the ability to suppress immune responses and expand during cancer, infection, and inflammatory diseases. Although MDSCs have attracted a lot of attention in the field of tumor immunology in...

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Bibliographic Details
Published inJournal of hematology and oncology Vol. 12; no. 1; p. 105
Main Authors Lv, Meng, Wang, Ke, Huang, Xiao-Jun
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 22.10.2019
BioMed Central
BMC
Subjects
B cells
Diagnosis
Hematological malignancies
Hematopoietic stem cell transplantation
Hematopoietic stem cells
Immune response
Leukemia
Lymphoma
Multiple myeloma
Myeloid-derived suppressor cells
Review
Transplantation
Lymphoma
Leukemia
Myeloid-derived suppressor cells
Hematological malignancies
Hematopoietic stem cell transplantation
Multiple myeloma
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Summary:Myeloid-derived suppressor cells (MDSCs) are newly identified immature myeloid cells that are characterized by the ability to suppress immune responses and expand during cancer, infection, and inflammatory diseases. Although MDSCs have attracted a lot of attention in the field of tumor immunology in recent years, little is known about their multiple roles in hematological malignancies as opposed to their roles in solid tumors. This review will help researchers better understand the various characteristics and functions of MDSCs, as well as the potential therapeutic applications of MDSCs in hematological malignancies, including lymphoma, multiple myeloma, leukemia, and hematopoietic stem cell transplantation.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1756-8722
1756-8722
DOI:10.1186/s13045-019-0797-3