Circulating inflammatory markers may mediate the relationship between low carbohydrate diet and circadian rhythm in overweight and obese women

• Published in: BMC women's health Vol. 21; no. 1; p. 87
• Main Authors: Tavakoli, Atefeh, Mirzababaei, Atieh, Sajadi, Forough, Mirzaei, Khadijeh
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.03.2021; BioMed Central; BMC
• Subjects: Binding proteins; Birth control; Body composition; Body fat; Body mass index; Carbohydrates; Cardiovascular disease; Cholesterol; Chronic illnesses; Circadian rhythm; Circadian rhythms; Cytokines; Diabetes; Diet; Fasting; Fatty acids; Glucose; Health aspects; Inflammation; Interleukin-1; Investigations; Low carbohydrate diet; Manufacturers; Meals; Metabolism; Obesity; Overweight; Physiological aspects; Proteins; Questionnaires; Transforming growth factors; Women; Womens health; Iran; Germany; Obesity; Low carbohydrate diet; Inflammation; Circadian rhythm
• ISSN: 1472-6874; 1472-6874
• DOI: 10.1186/s12905-021-01240-5

Low carbohydrate diet (LCD) can improve inflammation and obesity and also circadian rhythm disorders can lead to increased inflammation in obese individuals. The purpose of this study is to evaluate the association between adherence of LCD and circadian rhythm mediated by inflammatory markers including transforming growth factor-β (TGF-β), interleukin-1β (IL-1β) and Galectin-3 in overweight and obese women. 304 women affected by overweight and obesity were enrolled. We evaluated LCD scores by Semi-quantitative food frequency questionnaire (FFQ) of 147 items. The morning-evening questionnaire (MEQ) was applied to evaluate the circadian rhythm. Biochemical parameters such as inflammatory markers and anthropometric components were assessed. There was a negative significant correlation between adherence of LCD and circadian rhythm status. In other words, as the LCD scores increased, the odds of circadian rhythm disturbance in intermediate group and morning type persons decreased compared to evening type. It was showed that, IL-1β and Galectin-3 in intermediate and morning type groups, destroyed the significance of this relationship and may be considered as mediating markers. Adherence of LCD can improve the circadian rhythm by reducing levels of inflammatory markers and may be considered as a treatment for obesity.