Relapsed boyhood tibia polymicrobial osteomyelitis linked to dermatophytosis: a case report

• Published in: BMC surgery Vol. 22; no. 1; p. 156
• Main Authors: Kong, Ping, Ren, Youliang, Yang, Jin, Fu, Wei, Liu, Ziming, Li, Zhengdao, He, Wenbin, Wang, Yunying, Zheng, Zhonghui, Ding, Muliang, Schwarz, Edward M, Deng, Zhongliang, Xie, Chao
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.05.2022; BioMed Central; BMC
• Subjects: Anti-Bacterial Agents; Antibiotics; Antifungal agents; Biofilms; Biomedical materials; Biopsy; Care and treatment; Case Report; Child; Children; Coinfection - complications; Coinfection - diagnosis; Corynebacterium; Debridement; Dermatomycosis; Dermatophytosis; Fungal infections; Fungi; Health aspects; Histology; Humans; Immune system; Infections; Inflammation; Male; Methicillin; Microbiology; Middle Aged; Mycoses; Osteomyelitis; Osteomyelitis - complications; Osteomyelitis - diagnosis; Patients; Polymicrobial osteomyelitis; Potassium; Potassium permanganate; Prostheses; Proteins; Relapse; Skin; Staphylococcal Infections - complications; Staphylococcus aureus; Staphylococcus aureus infections; Staphylococcus infections; Tetracycline; Tetracyclines; Tibia; Tibia - surgery; Tinea - complications; Tissue culture; Tomography; Polymicrobial osteomyelitis; Relapse; Corynebacterium; Dermatophytosis; Staphylococcus aureus
• ISSN: 1471-2482; 1471-2482
• DOI: 10.1186/s12893-022-01600-4

Relapsed childhood polymicrobial osteomyelitis associated with dermatophytosis has not been reported in the literature. Here we report on a case of a 45-year-old man who had left tibial osteomyelitis for 29 years, accompanied by skin fungal infection of the ipsilateral heel for 20 years, and underwent a second operation due to recurrence of polymicrobial infection 6 years ago. The patient had a history of injury from a rusty object, which penetrated the anterior skin of the left tibia middle segment causing subsequent bone infection, but was asymptomatic after receiving treatments in 1983. The patient was physically normal until dermatophytosis occurred on the ipsilateral heel skin in 1998. The patient complained that the dermatophytosis was gradually getting worse, and the tibial wound site became itchy, red, and swollen. The left tibial infection resurged in May 2012, leading to the patient receiving debridement and antibiotic treatment. H&E and Gram-stained histology was performed on biopsy specimens of sequestrum and surrounding inflammatory tissue. Tissue culture and microbiology examination confirmed polymicrobial infection with Staphylococcus aureus (S. aureus) and Corynebacterium and a fungus. Additionally, the patient also received potassium permanganate for dermatophytosis when he was admitted into the hospital. Together with longitudinal follow-up of medical history, surgical findings, histopathological and microbiology culture evidence, we conclude that boyhood tibia polymicrobial osteomyelitis with S. aureus and Corynebacterium occurred in this patient, and the fungal activation of dermatophytosis may have led to osteomyelitis relapse.