Chinese expert consensus on diagnosis and treatment of trauma-induced hypercoagulopathy

• Published in: Military medical research Vol. 8; no. 1; p. 25
• Main Authors: Song, Jing-Chun, Yang, Li-Kun, Zhao, Wei, Zhu, Feng, Wang, Gang, Chen, Yao-Peng, Li, Wei-Qin
• Format: Journal Article
• Language: English
• Published: England BioMed Central 12.04.2021; BMC
• Subjects: Blood platelets; Coagulation dysfunction; Critical care; Cytokines; Diagnosis; Gastrointestinal surgery; Genotype & phenotype; Hemorrhagic shock; Inflammation; Mortality; Patients; Position article and Guidelines; Thromboembolism; Thrombosis; Trauma; Treatment; China; Treatment; Diagnosis; Thrombosis; Trauma; Coagulation dysfunction
• ISSN: 2054-9369; 2095-7467; 2054-9369
• DOI: 10.1186/s40779-021-00317-4

Trauma-induced coagulopathy (TIC) is caused by post-traumatic tissue injury and manifests as hypercoagulability that leads to thromboembolism or hypocoagulability that leads to uncontrollable massive hemorrhage. Previous studies on TIC have mainly focused on hemorrhagic coagulopathy caused by the hypocoagulable phenotype of TIC, while recent studies have found that trauma-induced hypercoagulopathy can occur in as many as 22.2-85.1% of trauma patients, in whom it can increase the risk of thrombotic events and mortality by 2- to 4-fold. Therefore, the Chinese People's Liberation Army Professional Committee of Critical Care Medicine and the Chinese Society of Thrombosis, Hemostasis and Critical Care, Chinese Medicine Education Association jointly formulated this Chinese Expert Consensus comprising 15 recommendations for the definition, pathophysiological mechanism, assessment, prevention, and treatment of trauma-induced hypercoagulopathy.