Never a rose without a prick: pseudohyperglycemia when administering high-dose intravenous vitamin C

When ascorbic acid is administered, it is oxidized at the surface of the monitor, resulting in the release of an electron and negative charge. [...]high-dosage intravenous ascorbic acid could yield false hyperglycemia measured by POC devices, which has been documented in burn patients receiving intr...

Full description

Saved in:
Bibliographic Details
Published inCritical care (London, England) Vol. 24; no. 1; pp. 251 - 2
Main Authors Zhang, Yongli, Huang, Wei
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 24.05.2020
BioMed Central
BMC
Subjects
Acids
Administration, Intravenous - methods
Antioxidants - adverse effects
Antioxidants - pharmacology
Antioxidants - therapeutic use
Ascorbic Acid - adverse effects
Ascorbic Acid - pharmacology
Ascorbic Acid - therapeutic use
Blood Glucose - analysis
Critical care
Glucose
Humans
Hyperglycemia
Hypoglycemia
Laboratories
Letter
Sepsis
Septic shock
Vitamin C
Online AccessGet full text

Cover

More Information
Summary:When ascorbic acid is administered, it is oxidized at the surface of the monitor, resulting in the release of an electron and negative charge. [...]high-dosage intravenous ascorbic acid could yield false hyperglycemia measured by POC devices, which has been documented in burn patients receiving intravenous vitamin C infusions (66 mg/kg/h) [4]. [...]when initiating high-dose vitamin C, physicians should be aware of the potential consequences of pseudohyperglycemia if employing POC devices for glucose monitoring. Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: the CITRIS-ALI randomized clinical trial.
ISSN:1364-8535
1466-609X
1364-8535
1366-609X
DOI:10.1186/s13054-020-02994-4