How cancer cells remodel lipid metabolism: strategies targeting transcription factors

• Published in: Lipids in health and disease Vol. 20; no. 1; p. 163
• Main Authors: Jeong, Do-Won, Lee, Seulbee, Chun, Yang-Sook
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 14.11.2021; BioMed Central; BMC
• Subjects: Antineoplastic Agents - pharmacology; Cancer; Cancer cells; Carcinogenesis; Cell division; Cell growth; Colorectal cancer; Enzymes; Factor analysis; Fatty acids; Gene expression; Genetic aspects; Glucose; Health aspects; Kinases; Lipid metabolism; Lipid Metabolism - physiology; Lipids; Mass spectrometry; Medical prognosis; Membranes; Metabolism; Metabolites; Metastases; Metastasis; Molecular Targeted Therapy - methods; Neoplasms - drug therapy; Neoplasms - immunology; Neoplasms - metabolism; Neoplasms - pathology; Phenotypes; Phosphorylation; Physiological aspects; Plasma; Prostate cancer; Proteins; Review; Scientific imaging; Transcription factor; Transcription factors; Transcription Factors - metabolism; South Korea; Transcription factor; Lipid metabolism; Cancer
• ISSN: 1476-511X; 1476-511X
• DOI: 10.1186/s12944-021-01593-8

Reprogramming of lipid metabolism has received increasing recognition as a hallmark of cancer cells because lipid dysregulation and the alteration of related enzyme profiles are closely correlated with oncogenic signals and malignant phenotypes, such as metastasis and therapeutic resistance. In this review, we describe recent findings that support the importance of lipids, as well as the transcription factors involved in cancer lipid metabolism. With recent advances in transcription factor analysis, including computer-modeling techniques, transcription factors are emerging as central players in cancer biology. Considering the limited number and the crucial role of transcription factors associated with lipid rewiring in cancers, transcription factor targeting is a promising potential strategy for cancer therapy.