Wilms' tumor: An update

Wilms' tumor (WT) is the commonest pediatric renal tumor, predominantly seen in children less than five years of age. The majority of patients present with an abdominal lump and CT scan is the usual imaging modality for determining the extent of disease. With multimodality management, the resul...

Full description

Saved in:
Bibliographic Details
Published inIndian journal of urology Vol. 23; no. 4; pp. 458 - 466
Main Authors Tongaonkar, Hemant B, Qureshi, Sajid S, Kurkure, Purna A, Muckaden, Mary-Ann A, Arora, Brijesh, Yuvaraja, Thyavihalli B
Format Journal Article
LanguageEnglish
Published India Medknow Publications and Media Pvt. Ltd 01.10.2007
Medknow Publications
Wolters Kluwer Medknow Publications
Subjects
Analysis
Care and treatment
Chemotherapy
Development and progression
Diagnosis
Genetic aspects
Health aspects
International Society of Pediatric Oncology
Medical protocols
National Wilms′ Tumor Study Group
Nephroblastoma
Prognosis
Risk factors
surgery
survival
Symposium
toxicity
Wilms′ tumor
India
toxicity
Chemotherapy
International Society of Pediatric Oncology
survival
National Wilms' Tumor Study Group
Wilms' tumor
surgery
Online AccessGet full text

Cover

More Information
Summary:Wilms' tumor (WT) is the commonest pediatric renal tumor, predominantly seen in children less than five years of age. The majority of patients present with an abdominal lump and CT scan is the usual imaging modality for determining the extent of disease. With multimodality management, the results of treatment of WT have improved dramatically over the last 50 years. The treatment protocols have been devised and modified repeatedly depending on evidence from randomized trials by several cooperative groups - mainly National Wilms' Tumor Study Group (NWTSG) and the International Society of Pediatric Oncology (SIOP). The NWTSG recommends primary surgery followed by chemotherapy while SIOP advocates four weeks of chemotherapy prior to surgery. The regimen, dose and duration of chemotherapy have been repeatedly modified to reduce toxicity while maintaining efficacy. The role of radiation therapy has also been customized. Most centers have reported excellent survival rates with the modern day treatment protocols, except in patients with an unfavorable histology. The results of treatment of relapsed WT have also improved with newer drugs and combinations being used for the same.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0970-1591
1998-3824
DOI:10.4103/0970-1591.36722