Has the non-resection rate decreased during the last two decades among patients undergoing surgical exploration for pancreatic adenocarcinoma?

• Published in: BMC surgery Vol. 20; no. 1; p. 176
• Main Authors: Mattevi, C, Garnier, J, Marchese, U, Ewald, J, Gilabert, M, Poizat, F, Piana, G, Delpero, J R, Turrini, O
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05.08.2020; BioMed Central; BMC
• Subjects: Abdomen; Adenocarcinoma; Adenocarcinoma - diagnostic imaging; Adenocarcinoma - surgery; Adult; Aged; Aged, 80 and over; Aorta; Cancer metastasis; Carcinoma, Pancreatic Ductal - diagnostic imaging; Carcinoma, Pancreatic Ductal - surgery; Care and treatment; CAT scans; Computed tomography; Contraindications; Diffusion Magnetic Resonance Imaging; Female; Health aspects; Humans; Laparoscopy; Laparotomy; Liver; Liver MRI; Lymph nodes; Lymphatic system; Magnetic resonance imaging; Male; Medical imaging; Metastases; Metastasis; Middle Aged; Mortality; Multivariate analysis; Pancreas; Pancreatectomy - statistics & numerical data; Pancreatic adenocarcinoma; Pancreatic cancer; Pancreatic Neoplasms - diagnostic imaging; Pancreatic Neoplasms - surgery; Patients; Retrospective Studies; Staging; Surgery; Survival analysis; Tomography; United States > US; Pancreatic adenocarcinoma; CT; Liver MRI; Staging
• ISSN: 1471-2482; 1471-2482
• DOI: 10.1186/s12893-020-00835-3

To determine if improvement in imaging reduces the non-resection rate (NRR) among patients with pancreatic ductal adenocarcinoma (PDAC). From 2000 to 2019, 751 consecutive patients with PDAC were considered eligible for a intention-to-treat pancreatectomy and entered the operating room. In April 2011, our institution acquired a dual energy spectral computed tomography (CT) scanner and liver diffusion weighted magnetic resonance imaging (DW-MRI) was included in the imaging workup. We consequently considered 2 periods of inclusion: period #1 (February 2000-March 2011) and period #2 (April 2011-August 2019). All patients underwent a preoperative CT scan with a median delay to surgery of 18 days. Liver DW-MRI was performed among 407 patients (54%). Median delay between CT and surgery decreased (21 days to 16 days, P < .01), and liver DW-MRI was significantly most prescribed during period #2 (14% vs 75%, P < .01). According to the intraoperative findings, the overall NRR was 24.5%, and remained stable over the two periods (25% vs 24%, respectively). While vascular invasion, liver metastasis, and carcinomatosis rates remained stable, para-aortic lymph nodes invasion rate (0.4% vs 4.6%; P < 0.001) significantly increased over the 2 periods. The mean size of the bigger extra pancreatic tumor significantly decrease (7.9 mm vs 6.4 mm (P < .01), respectively) when the resection was not done. In multivariate analysis, CA 19-9 < 500 U/mL (P < .01), and liver DW-MRI prescription (P < .01) favoured the resection. Due to changes in our therapeutic strategies, the NRR did not decrease during two decades despite imaging improvement.