Intracellular galectins sense cytosolically exposed glycans as danger and mediate cellular responses

Galectins are animal lectins that recognize carbohydrates and play important roles in maintaining cellular homeostasis. Recent studies have indicated that under a variety of challenges, intracellular galectins bind to host glycans displayed on damaged endocytic vesicles and accumulate around these d...

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Published inJournal of biomedical science Vol. 28; no. 1; p. 16
Main Authors Hong, Ming-Hsiang, Weng, I-Chun, Li, Fang-Yen, Lin, Wei-Han, Liu, Fu-Tong
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 04.03.2021
BioMed Central
BMC
Subjects
Adapter proteins
Adenoviruses
Autophagy
Bacteria
Bacterial infections
Carbohydrates
Damage accumulation
Galectin
Glycans
Health aspects
Homeostasis
Infection
Infections
Intracellular
Lectins
Ligands
Listeria
Microscopy
Molecular modelling
Organelles
Peptides
Phagocytosis
Polysaccharides
Review
Salmonella
Viral infections
Galectin
Infection
Carbohydrates
Glycans
Autophagy
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Summary:Galectins are animal lectins that recognize carbohydrates and play important roles in maintaining cellular homeostasis. Recent studies have indicated that under a variety of challenges, intracellular galectins bind to host glycans displayed on damaged endocytic vesicles and accumulate around these damaged organelles. Accumulated galectins then engage cellular proteins and subsequently control cellular responses, such as autophagy. In this review, we have summarized the stimuli that lead to the accumulation of galectins, the molecular mechanisms of galectin accumulation, and galectin-mediated cellular responses, and elaborate on the differential regulatory effects among galectins.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1423-0127
1021-7770
1423-0127
DOI:10.1186/s12929-021-00713-x