Age distribution and associated factors of cornea biomechanical parameter stress-strain index in Chinese healthy population

• Published in: BMC ophthalmology Vol. 20; no. 1; pp. 436 - 6
• Main Authors: Liu, Guihua, Rong, Hua, Pei, Ruxia, Du, Bei, Jin, Nan, Wang, Di, Jin, Chengcheng, Wei, Ruihua
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 03.11.2020; BioMed Central; BMC
• Subjects: Age composition; Age Distribution; Age groups; Analysis; Anterior chamber; Anterior segment parameters; Biomechanical Phenomena; Biomechanics; China - epidemiology; Chinese population; Cornea; Corneal biomechanics; Corvis ST; Humans; Intraocular Pressure; Mechanical properties; Normal distribution; Ophthalmology; Population; Real estate appraisal; Statistical analysis; Stress-strain index; Surgery; Tonometry, Ocular; China; Germany; Chinese population; Corneal biomechanics; Stress-strain index; Anterior segment parameters; Corvis ST
• ISSN: 1471-2415; 1471-2415
• DOI: 10.1186/s12886-020-01704-6

To investigate the new cornea biomechanical parameter stress-strain index (SSI) in Chinese healthy people and the factors associated with SSI. A total of 175 eyes from 175 participants were included in this study. Axial length was measured with the Lenstar LS-900. Pentacam measured curvature of the cornea and anterior chamber volume (ACV). Cornea biomechanical properties assessments were performed by corneal visualization Scheimpflug technology (Corvis ST). Student's t-test, one-way ANOVA, partial least square linear regression (PLSLR) and linear mixed effects (LME) model were used in the statistical analysis. The mean (±SD) SSI was 1.14 ± 0.22 (range, 0.66-1.78) in all subjects and affected by age significantly after age of 35 (P < 0.05). In LME models, SSI was significantly associated with age (β = 0.526, P < 0.001), axial length (AL) (β = - 0.541, P < 0.001), intraocular pressure (IOP) (β = 0.326, P < 0.001) and steepest radius of anterior corneal curvature (RsF) (β = 0.229, P < 0.001) but not with ACV, biomechanical corrected intraocular pressure (bIOP), flattest radius of anterior corneal curvature (RfF) or central corneal thickness (CCT) (P > 0.05 for each). SSI increased with age after the age of 35. In addition to age, SSI was positively correlated with RsF and IOP, while negatively correlated with AL.