Effects and mechanism of renal denervation on ventricular arrhythmia after acute myocardial infarction in rats

• Published in: BMC cardiovascular disorders Vol. 22; no. 1; p. 544
• Main Authors: Ye, Jian, Xiao, Rongxue, Wang, Xu, He, Ruiqing, Liu, Zongjun, Gao, Junqing
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 12.12.2022; BioMed Central; BMC
• Subjects: Abdomen; Acute myocardial infarction; Animals; Arrhythmia; Arrhythmias, Cardiac - etiology; Arrhythmias, Cardiac - metabolism; Arrhythmias, Cardiac - prevention & control; Cardiac arrhythmia; Care and treatment; Central nervous system; Cerebrospinal fluid; Complications and side effects; Denervation; Enzymes; Health aspects; Heart attack; Heart attacks; Hypothalamus; Ischemia; Kidney; Kidneys; Laboratory animals; Medical dressings; Medical prognosis; Methods; Myocardial Infarction; Nerve growth factor; Norepinephrine; Performance evaluation; Phenols; Physiological aspects; Protein expression; Rats; Rats, Sprague-Dawley; Renal artery; Renal denervation; Renal plexus; Software; Sympathectomy; Sympathetic nerve; Sympathetic nerves; Sympathetic Nervous System - metabolism; Sympathetic Nervous System - surgery; Tachycardia; Veins & arteries; Ventricle; Ventricular arrhythmia; γ-Aminobutyric acid; China; Renal denervation; Sympathetic nerve; Ventricular arrhythmia; Acute myocardial infarction; Central nervous system
• ISSN: 1471-2261; 1471-2261
• DOI: 10.1186/s12872-022-02980-4

Renal denervation (RDN) can reduce ventricular arrhythmia after acute myocardial infarction (AMI), but the mechanism is not clear. The purpose of this study is to study its mechanism. Thirty-two Sprague-Dawley rats were divided into four groups: control group, AMI group, RDN-1d + AMI group, RDN-2w + AMI group. The AMI model was established 1 day after RDN in the RDN-1d + AMI group and 2 weeks after RDN in the RDN-2w + AMI group. At the same time, 8 normal rats were subjected to AMI modelling (the AMI group). The control group consisted of 8 rats without RDN intervention or AMI modelling. The study confirmed that RDN can reduce the occurrence of ventricular tachycardia in AMI rats, reduce renal sympathetic nerve discharge, and inhibit the activity of local sympathetic nerves and cell growth factor (NGF) protein expression in the heart after AMI. In addition, RDN decreased the expression of norepinephrine (NE) and glutamate in the hypothalamus,and NE in cerebrospinal fluid, and increased the expression level of γ aminobutyric acid (GABA) in the hypothalamus after AMI. RDN can effectively reduce the occurrence of ventricular arrhythmia after AMI, and its main mechanism may be via the inhibition of central sympathetic nerve discharge.