The impact of healthcare worker influenza vaccination on nosocomial influenza in a tertiary hospital: an ecological study

• Published in: BMC health services research Vol. 20; no. 1; pp. 636 - 6
• Main Authors: Wei, Wycliffe Enli, Fook-Chong, Stephanie, Chen, Wen Kai, Chlebicki, Maciej Piotr, Gan, Wee Hoe
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 10.07.2020; BioMed Central; BMC
• Subjects: Cross infection; Cross Infection - epidemiology; Cross Infection - prevention & control; Ecological studies; Female; Health personnel; Health Personnel - statistics & numerical data; Health services; Healthcare-associated; Hospitals; Humans; Immunization; Incidence; Influenza; Influenza vaccines; Influenza Vaccines - therapeutic use; Influenza, Human - epidemiology; Influenza, Human - prevention & control; Laboratories; Male; Medical personnel; Microbial ecology; Officials and employees; Patients; Prevention; Risk factors; Safety and security measures; Sensitivity analysis; Singapore; Singapore - epidemiology; Statistical analysis; Statistical significance; Surveillance; Tertiary Care Centers - statistics & numerical data; Testing; Trends; Vaccination; Vaccination - statistics & numerical data; Vaccination coverage; Vaccines; Singapore; Southern Hemisphere; Cross infection; Health personnel; Vaccination coverage; Healthcare-associated; Influenza; Vaccination
• ISSN: 1472-6963; 1472-6963
• DOI: 10.1186/s12913-020-05490-1

To protect hospitalized patients, who are more susceptible to complications of influenza, seasonal influenza vaccination of healthcare workers (HCW) has been recommended internationally. However, its effectiveness is still being debated. To assess the effectiveness of HCW influenza vaccination, we performed an ecological study to evaluate the association between healthcare worker influenza vaccination and the incidence of nosocomial influenza in a tertiary hospital within Singapore between 2013 and 2018. Nosocomial influenza was defined as influenza among inpatients diagnosed 7 days or more after admission by laboratory testing, while healthcare worker influenza vaccination rate was defined as the proportion of healthcare workers that was vaccinated at the end of each annual seasonal vaccination exercise. A modified Poisson regression was performed to assess the association between the HCW vaccination rates and monthly nosocomial influenza incidence rates. Nosocomial influenza incidence rates followed the trend of non-nosocomial influenza, showing a predominant mid-year peak. Across 2,480,010 patient-days, there were 256 nosocomial influenza cases (1.03 per 10,000 patient-days). Controlling for background influenza activity and the number of influenza tests performed, no statistically significant association was observed between vaccination coverage and nosocomial influenza incidence rate although a protective effect was suggested (IRR 0.89, 95%CI:0.69-1.15, p = 0.37). No significant association was observed between influenza vaccination rates and nosocomial influenza incidence rates, although a protective effect was suggested. Aligning local HCW vaccine timing and formulation to that of the Southern Hemisphere may improve effectiveness. HCW vaccination remains important but demonstrating its effectiveness in preventing nosocomial influenza is challenging.