Endometrial expression of relaxin and relaxin receptor in endometriosis

• Published in: Fertility and sterility Vol. 94; no. 7; pp. 2885 - 2887
• Main Authors: Morelli, Sara S., M.D, Petraglia, Felice, M.D, Weiss, Gerson, M.D, Luisi, Stefano, M.D., Ph.D, Florio, Pasquale, M.D, Wojtczuk, Andrea, M.S, Goldsmith, Laura T., Ph.D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.12.2010; Elsevier
• Subjects: Adult; Biological and medical sciences; Case-Control Studies; endometriosis; Endometriosis - genetics; Endometriosis - metabolism; Endometriosis - pathology; endometrium; Endometrium - metabolism; Endometrium - pathology; Female; Female genital diseases; Gene Expression - physiology; Gynecology. Andrology. Obstetrics; Humans; Internal Medicine; LGR7; Medical sciences; Menstrual Cycle - genetics; Menstrual Cycle - metabolism; Menstrual Cycle - physiology; Non tumoral diseases; Obstetrics and Gynecology; Ovarian Diseases - genetics; Ovarian Diseases - metabolism; Ovarian Diseases - pathology; Receptors, G-Protein-Coupled - genetics; Receptors, G-Protein-Coupled - metabolism; Receptors, G-Protein-Coupled - physiology; Receptors, Peptide - genetics; Receptors, Peptide - metabolism; Receptors, Peptide - physiology; Relaxin; Relaxin - genetics; Relaxin - metabolism; Relaxin - physiology; relaxin receptor; Young Adult; endometriosis; endometrium; LGR7; Relaxin; relaxin receptor; Gynecology; Peptide hormone; Uterine diseases; Endometriosis; Obstetrics; Endometrium; Female genital diseases
• ISSN: 0015-0282; 1556-5653
• DOI: 10.1016/j.fertnstert.2010.06.051

Our studies demonstrate significantly lower expression of relaxin and its receptor in ectopic endometriotic tissues than their expression in eutopic endometrium and in endometrium from normal controls. These data suggest that in normal and eutopic endometrium, relaxin may exert a protective effect against endometriosis.