Dynamic hematological changes in patients undergoing distal pancreatectomy with or without splenectomy: a population-based cohort study

• Published in: BMC surgery Vol. 20; no. 1; p. 265
• Main Authors: Cui, Ming, Liu, Jing-Kai, Zheng, Bang, Liu, Qiao-Fei, Zhang, Lu, Zhang, Li, Guo, Jun-Chao, Dai, Meng-Hua, Zhang, Tai-Ping, Liao, Quan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 31.10.2020; BioMed Central; BMC
• Subjects: Analysis; Bias; Blood; Blood platelets; Blood vessels; Cohort analysis; Cohort Studies; Distal pancreatectomy; Erythrocytes; Female; Hematologic Diseases - blood; Hematologic Diseases - diagnosis; Hematologic Diseases - etiology; Hematologic Tests; Hematology; Hemoglobin; Hospitals; Humans; Immunology; Laboratories; Laparoscopy; Leukocyte; Lymphocytes; Male; Monocytes; Neutrophils; Pancreas; Pancreatectomy; Pancreatectomy - adverse effects; Pancreatic Neoplasms - blood; Pancreatic Neoplasms - surgery; Parameters; Patients; Platelet; Population studies; Population-based studies; Spleen; Spleen preservation; Splenectomy; Splenectomy - adverse effects; Statistical analysis; Surgeons; Surgery; Surgical techniques; Treatment Outcome; Tumors; Variables; United States > US; Splenectomy; Platelet; Distal pancreatectomy; Leukocyte; Spleen preservation
• ISSN: 1471-2482; 1471-2482
• DOI: 10.1186/s12893-020-00931-4

The clinical outcomes of patients who received distal pancreatectomy with splenectomy (DPS) and spleen-preserving distal pancreatectomy (SPDP) have been generally investigated. However, postoperative hematological changes after distal pancreatectomy with or without splenectomy are poorly understood. Information from patients undergoing distal pancreatectomy (DP) between January 2014 and June 2019 at a single institution was reviewed. A linear mixed-effects model was used to compare dynamic hematological changes between different groups. A total of 302 patients who underwent DP were enrolled. In the long term, most postoperative hematological parameters remained significantly higher than preoperative levels in the DPS group, while postoperative lymphocyte, monocyte, basophil, and platelet levels returned to preoperative levels in the SPDP group. All postoperative hematological parameters except for red blood cell count and serum hemoglobulin level were significantly higher in the DPS group than in the SPDP group. There were no significant differences in hematological changes between the splenic vessel preservation (SVP) and Warshaw technique (WT) groups. Postoperative hematological changes were significantly different between the DPS and SPDP groups. Compared to DPS, SPDP reduced abnormal hematological changes caused by splenectomy. SVP and WT were comparable in terms of postoperative hematological changes.