Sex-related differences in single nucleotide polymorphisms associated with dyslipidemia in a Korean population

• Published in: Lipids in health and disease Vol. 21; no. 1; pp. 124 - 13
• Main Authors: Lee, Gyeonghee, Jeon, Hye Kyung, Yoo, Hae Young
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 23.11.2022; BioMed Central; BMC
• Subjects: Age; Apolipoprotein E; Apolipoproteins E - genetics; Atherosclerosis; Cardiovascular disease; Cholesterol; Demographics; Dyslipidemia; Dyslipidemias; Dyslipidemias - epidemiology; Epidemiology; Family medical history; Female; Gender differences; Gene polymorphism; Genetic aspects; Genetic Predisposition to Disease; Genome-wide association analysis; Genome-wide association studies; Genome-Wide Association Study; Genomes; Genotyping; Health aspects; High density lipoprotein; Humans; Lipids; Male; Menopause; Metabolic disorders; Patients; Polymorphism, Single Nucleotide - genetics; Population genetics; Population studies; Quality control; Sex; Sex differences; Sex factors in disease; Sex-related difference; Single nucleotide polymorphism; Single nucleotide polymorphisms; Womens health; South Korea; Single nucleotide polymorphism; Sex-related difference; Dyslipidemia; Genome-wide association analysis
• ISSN: 1476-511X; 1476-511X
• DOI: 10.1186/s12944-022-01736-5

The prevalence of dyslipidemia has increased steadily in Korea, and the incidence of dyslipidemia differs by sex. In this study, we identified single nucleotide polymorphisms (SNPs) related to dyslipidemia in Korean cohorts through genome-wide association study (GWAS) analysis. Genotyping was conducted to determine the genotypes of 72,298 participants and investigate genotypes for 7,079,946 SNPs. Sex, age, and BMI were set as covariates for GWAS, and significant SNPs were identified in the discovery and replication stages using logistic regression. GWAS of the entire cohort revealed a total of five significant SNPs: rs117026536 (LPL), rs651821 (APOA5), rs9804646 (APOA5), rs9926440 (CETP), and rs429358 (APOE). GWAS of the male subjects revealed a total of four significant SNPs. While rs9804646 (APOA5) and rs429358 (APOE) were significant for all the subjects, rs662799 (APOA5) and rs56156922 (CETP) were significant only for the male subjects. GWAS of the female subjects revealed two significant SNPs, rs651821 (APOA5) and rs9804646 (APOA5), both of which were significant in all the subjects. This is the first study to identify sex-related differences in genetic polymorphisms in Korean populations with dyslipidemia. Further studies considering environmental variables will be needed to elucidate these sex-related genetic differences in dyslipidemia.