The relationship between changes in serum myostatin and adiponectin levels in patients with obesity undergoing a weight loss program

• Published in: BMC endocrine disorders Vol. 21; no. 1; p. 147
• Main Authors: Takao, Nana, Kurose, Satoshi, Miyauchi, Takumi, Onishi, Katsuko, Tamanoi, Atsuko, Tsuyuguchi, Ryota, Fujii, Aya, Yoshiuchi, Sawako, Takahashi, Kazuhisa, Tsutsumi, Hiromi, Kimura, Yutaka
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 08.07.2021; BioMed Central; BMC
• Subjects: Adiponectin; Adiponectin - blood; Adipose Tissue - physiology; Adult; Aerobics; Anaerobic threshold; Blood; Body composition; Body Composition - physiology; Body fat; Body Mass Index; Body Weight; Body weight loss; Cardiac stress tests; Care and treatment; Diet; Exercise; Exercise Test; Exercise Therapy - methods; Female; Humans; Insulin; Insulin resistance; Lean body mass; Lean mass; Male; Medical examination; Medical records; Medical research; Medicine, Experimental; Metabolism; Middle Aged; Muscle Strength; Muscle, Skeletal - physiology; Muscles; Musculoskeletal system; Myostatin; Myostatin - blood; Obesity; Obesity - blood; Obesity - therapy; Overweight; Patients; Physical fitness; Physiological aspects; Questionnaires; Retrospective Studies; Skeletal muscle; Surveys and Questionnaires; Weight control; Weight loss; Weight Loss - physiology; Weight Reduction Programs; Japan; Minneapolis Minnesota; United States > US; Lean mass; Myostatin; Body composition; Weight loss; Adiponectin
• ISSN: 1472-6823; 1472-6823
• DOI: 10.1186/s12902-021-00808-4

An effective strategy for weight loss in patients who are overweight or obese is to reduce body fat mass while maintaining skeletal muscle mass. Adiponectin and myostatin are affected through changes in body composition due to weight loss, and examining their dynamics may contribute to strategies for maintaining skeletal muscle mass through weight loss. We aimed to examine the relationships among myostatin, adiponectin, and body composition, depending on the extent of weight loss, in patients with obesity undergoing a weight loss program. We examined 66 patients with obesity (age: 46.8 ± 14.0 years, body mass index: 34.3 [31.0-38.4] kg/m ) attending a hospital weight loss program. We categorized the patients into two groups, namely an L group (those with a weight reduction of < 5% from baseline) and an M group (those with a weight reduction of > 5% from baseline). All patients underwent blood tests and were assessed for body composition, insulin resistance, adipocytokine and myokine levels, exercise tolerance, and muscle strength at baseline and post-intervention. Serum myostatin and adiponectin levels increased post-intervention in both groups. Body weight and %fat decreased, and the rate of lean body mass (%LBM) increased in both groups. Exercise capacity and muscle strength improved in the M group only. Change in (⊿) myostatin correlated with ⊿%fat, ⊿%LBM, and ⊿adiponectin. ⊿adiponectin (β = - 0.262, p = 0.035) was an independent predictor of ⊿myostatin. Myostatin and adiponectin might cross-talk and regulate changes in skeletal muscle and fat mass with or without successful weight loss. These findings indicate that evaluating serum myostatin and adiponectin levels in clinical practice could be used to predict the effects of weight loss and help prevent skeletal muscle mass loss.