Quantitative Trait Loci for Body Weight in the Intercross between SM/J and A/J Mice

• Published in: Experimental Animals Vol. 50; no. 4; pp. 319 - 324
• Main Authors: ANUNCIADO, Rea Victoria P., NISHIMURA, Masahiko, MORI, Masayuki, ISHIKAWA, Akira, TANAKA, Shin, HORIO, Fumihiko, OHNO, Tamio, NAMIKAWA, Takao
• Format: Journal Article
• Language: English
• Published: Japan Japanese Association for Laboratory Animal Science 01.07.2001
• Subjects: Alleles; Animals; body weight; Body Weight - genetics; Chromosome Mapping; Female; Genetic Markers; Genetic Variation; interval mapping; Male; Mice; Mice, Inbred Strains; mouse; Pedigree; Phenotype; quantitative trait loci (QTLs); Quantitative Trait, Heritable
• ISSN: 1341-1357; 1881-7122
• DOI: 10.1538/expanim.50.319

We performed a genome-wide quantitative trait locus (QTL) analysis of body weight at 10 weeks of age in a population of 321 intercross offspring from SM/J and A/J mice, progenitor strains of SMXA recombinant inbred strains. Interval mapping revealed two significant QTLs, Bwq3 (body weight QTL3) and Bwq4, on Chromosomes (Chrs) 8 and 18 respectively, and five suggestive QTLs on Chrs 2, 6, 7, 15 and 19. Bwq3 and Bwq4 explained 6% of the phenotypic variance. The SM/J alleles at both QTLs increased body weight, though the SM/J mouse was smaller than the A/J mouse. On the other hand, four of the five suggestive QTLs detected had male-specific effects on body weight and the remainder was female-specific. These suggestive QTLs explained 5-6% of the phenotypic variance and all the SM/J alleles decreased body weight.