Extracorporeal membrane oxygenation in non-intubated immunocompromised patients

• Published in: Critical care (London, England) Vol. 25; no. 1; p. 164
• Main Authors: Stahl, Klaus, Schenk, Heiko, Kühn, Christian, Wiesner, Olaf, Hoeper, Marius M, David, Sascha
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.04.2021; BioMed Central; BMC
• Subjects: Acute respiratory distress syndrome; Blood oxygenation, Extracorporeal; Care and treatment; Critical care; Drug dosages; Ethics; Extracorporeal membrane oxygenation; Immunocompromised host; Intensive care; Intubation; Medical schools; Methods; Mortality; Pathophysiology; Patients; Pneumonia; Research Letter; Respiratory distress syndrome; Stem cells; Systematic review; Transplants & implants; Ventilators; Germany
• ISSN: 1364-8535; 1466-609X; 1364-8535; 1366-609X
• DOI: 10.1186/s13054-021-03584-8

Ventilator-induced lung injury, ventilator-acquired pneumonia and ventilator-induced diaphragm dysfunction are severe side effects of invasive ventilation and may contribute to the complex pathophysiology of multi-organ failure and death in ARDS [2]. In immunocompromised patients with ARDS who require ECMO support, the 6-month mortality exceeds 70% with a reported in-hospital mortality of 81% in patients following hematopoietic stem cell transplantation (HSCT) [5]. Despite these limitations, our findings support the notion that an awake ECMO strategy might be a viable treatment option for immunocompromised patients with severe ARDS, especially in those patients without overt multi-organ failure. Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.