Intrinsic brain abnormalities of irritable bowel syndrome with diarrhea: a preliminary resting-state functional magnetic resonance imaging study

• Published in: BMC medical imaging Vol. 21; no. 1; p. 4
• Main Authors: Ao, Weiqun, Cheng, Yougen, Chen, Mingxian, Wei, Fuquan, Yang, Guangzhao, An, Yongyu, Mao, Fan, Zhu, Xiandi, Mao, Guoqun
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.01.2021; BioMed Central; BMC
• Subjects: Abnormalities; Brain; Brain mapping; Correlation analysis; Cortex (parietal); Data analysis; Diarrhea; Fractional amplitude of low-frequency fluctuations; Frontal gyrus; Functional; Functional magnetic resonance imaging; Hippocampus; Intestine; Irritable bowel syndrome; Magnetic resonance imaging; Medical imaging; Medical imaging equipment; Microbiota; Nervous system; Neuroimaging; Neurons; Pain; Pathogenesis; Power; Resonance; rsfMRI; X-ray computed; Canada; Montreal Quebec Canada; Functional; Fractional amplitude of low-frequency fluctuations; rsfMRI; X-ray computed; Irritable bowel syndrome
• ISSN: 1471-2342; 1471-2342
• DOI: 10.1186/s12880-020-00541-9

The aim of the present study was to explore the brain active characteristics of patients with irritable bowel syndrome with diarrhea (IBS-D) using resting-state functional magnetic resonance imaging technology. Thirteen IBS-D patients and fourteen healthy controls (HC) were enrolled. All subjects underwent head MRI examination during resting state. A voxel-based analysis of fractional amplitude of low frequency fluctuation (fALFF) maps between IBS-D and HC was performed using a two-sample t-test. The relationship between the fALFF values in abnormal brain regions and the scores of Symptom Severity Scale (IBS-SSS) were analyzed using Pearson correlation analysis. Compared with HC, IBS-D patients had lower fALFF values in the left medial superior frontal gyrus and higher fALFF values in the left hippocampus and right precuneus. There was a positive correlation between the duration scores of IBS-SSS and fALFF values in the right precuneus. The altered fALFF values in the medial superior frontal gyri, left hippocampus and right precuneus revealed changes of intrinsic neuronal activity, further revealing the abnormality of gut-brain axis of IBS-D.