Circular RNAs in osteoarthritis: indispensable regulators and novel strategies in clinical implications

Over the past decades, circular RNAs (circRNAs) have emerged as a hot spot and sparked intensive interest. Initially considered as the transcriptional noises, further studies have indicated that circRNAs are crucial regulators in multiple cellular biological processes, and thus engage in the develop...

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Published inArthritis research & therapy Vol. 23; no. 1; p. 23
Main Authors Zhang, Wenchao, Qi, Lin, Chen, Ruiqi, He, Jieyu, Liu, Zhongyue, Wang, Wanchun, Tu, Chao, Li, Zhihong
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 12.01.2021
BioMed Central
BMC
Subjects
Apoptosis
Arthritis
Autophagy
Binding sites
Biosynthesis
Cartilage
Chondrocytes
Circular RNAs
Diagnosis
Extracellular matrix
Gene expression
Health aspects
Inflammation
Kinases
Microenvironment
Nonsteroidal anti-inflammatory drugs
Osteoarthritis
Pathogenesis
Properties
Proteins
Review
RNA
Tumor necrosis factor-TNF
China
Extracellular matrix
Microenvironment
Osteoarthritis
Circular RNAs
Chondrocytes
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Summary:Over the past decades, circular RNAs (circRNAs) have emerged as a hot spot and sparked intensive interest. Initially considered as the transcriptional noises, further studies have indicated that circRNAs are crucial regulators in multiple cellular biological processes, and thus engage in the development and progression of many diseases including osteoarthritis (OA). OA is a prevalent disease that mainly affects those aging, obese and post-traumatic population, posing as a major source of socioeconomic burden. Recently, numerous circRNAs have been found aberrantly expressed in OA tissues compared with counterparts. More importantly, circRNAs have been demonstrated to interplay with components in OA microenvironments, such as chondrocytes, synoviocytes and macrophages, by regulation of their proliferation, apoptosis, autophagy, inflammation, or extracellular matrix reorganization. Herein, in this review, we extensively summarize the roles of circRNAs in OA microenvironment, progression, and putative treatment, as well as envision the future directions for circRNAs research in OA, with the aim to provide a novel insight into this field.
Bibliography:ObjectType-Article-2
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ISSN:1478-6362
1478-6354
1478-6362
DOI:10.1186/s13075-021-02420-2