The increased in vivo firing of pyramidal cells but not interneurons in the anterior cingulate cortex after neuropathic pain

Chronic pain damages the balance between excitation and inhibition in the sensory cortex. It has been confirmed that the activity of cortical glutamatergic pyramidal cells increases after chronic pain. However, whether the activity of inhibitory interneurons synchronized changed remains obscure, esp...

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Published inMolecular brain Vol. 15; no. 1; p. 12
Main Authors Zhu, Da-Yu, Cao, Ting-Ting, Fan, Hong-Wei, Zhang, Ming-Zhe, Duan, Hao-Kai, Li, Jing, Zhang, Xia-Jing, Li, Yun-Qing, Wang, Pan, Chen, Tao
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 29.01.2022
BioMed Central
BMC
Subjects
Analgesics
Anterior cingulate cortex
Brain
Chronic illnesses
Chronic pain
Cortex (cingulate)
Cortex (somatosensory)
Firing rate
Glutamatergic transmission
Hypersensitivity
In vivo multi-channel recording
Interneuron
Interneurons
Mice
Neuralgia
Neurons
Neuropathic pain
Pain
Pain perception
Pyramidal cell
Pyramidal cells
Sensory neurons
Pyramidal cell
Mice
Anterior cingulate cortex
In vivo multi-channel recording
Interneuron
Neuropathic pain
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Summary:Chronic pain damages the balance between excitation and inhibition in the sensory cortex. It has been confirmed that the activity of cortical glutamatergic pyramidal cells increases after chronic pain. However, whether the activity of inhibitory interneurons synchronized changed remains obscure, especially in in vivo conditions. In the present study, we checked the firing rate of pyramidal cells and interneurons in the anterior cingulate cortex, a main cortical area for the regulation of nociceptive information in mice with spared nerve injury by using in vivo multi-channel recording system. We found that the firing rate of pyramidal cells but not interneurons increased in the ACC, which was further confirmed by the increased FOS expression in pyramidal cells but not interneurons, in mice with neuropathic pain. Selectively high frequency stimulation of the ACC nociceptive afferent fibers only potentiated the activity of pyramidal cells either. Our results thus suggest that the increased activity of pyramidal cells contributes to the damaged E/I balance in the ACC and is important for the pain hypersensitivity in mice with neuropathic pain.
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ISSN:1756-6606
1756-6606
DOI:10.1186/s13041-022-00897-9