COVID-19 patients exhibit less pronounced immune suppression compared with bacterial septic shock patients

SEE PDF] Although mHLA-DR expression levels in COVID-19 patients were lower than those observed in healthy subjects (15,000–45,000 mAb/cell [5]), the extent of suppression was less pronounced than observed in bacterial septic shock patients (geometric mean [95% CI] of 11,860 [11,035–12,746] vs. 5211...

Full description

Saved in:
Bibliographic Details
Published inCritical care (London, England) Vol. 24; no. 1; pp. 263 - 4
Main Authors Kox, Matthijs, Frenzel, Tim, Schouten, Jeroen, van de Veerdonk, Frank L., Koenen, Hans J. P. M., Pickkers, Peter
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 26.05.2020
BioMed Central
BMC
Subjects
Aged
Betacoronavirus - immunology
Comparative analysis
Coronavirus Infections - immunology
Coronavirus Infections - metabolism
Coronaviruses
COVID
COVID-19
Critical care
Cytokines
EDTA
Exhibitions
Female
HLA-DR
Humans
Immune Tolerance - physiology
Infections
Intensive care
Intensive Care Units - trends
Male
mHLA-DR
Middle Aged
Monocytes
Pandemics
Patients
Pneumonia, Viral - immunology
Pneumonia, Viral - metabolism
Prospective Studies
Research Letter
SARS-CoV-2
Sepsis
Septic shock
Severe acute respiratory syndrome coronavirus 2
Shock, Septic - immunology
Shock, Septic - metabolism
Software
United States > US
Netherlands
China
COVID
COVID-19
Monocytes
SARS-CoV-2
HLA-DR
Immune suppression
mHLA-DR
Online AccessGet full text

Cover

More Information
Summary:SEE PDF] Although mHLA-DR expression levels in COVID-19 patients were lower than those observed in healthy subjects (15,000–45,000 mAb/cell [5]), the extent of suppression was less pronounced than observed in bacterial septic shock patients (geometric mean [95% CI] of 11,860 [11,035–12,746] vs. 5211 [4904–5537] mAb/cell, respectively; p < 0.0001; Fig. 1a, sepsis data from [1]). mHLA-DR expression kinetics revealed no change over time (Fig. 1b). SEE PDF] In conclusion, despite a pronounced inflammatory response in COVID-19 patients, our preliminary results indicate more moderate innate immune suppression compared with bacterial septic shock patients. [...]innate immune suppression as a negative feedback mechanism following pathogen-associated molecular pattern-induced inflammation appears less pronounced in COVID-19.
Bibliography:SourceType-Scholarly Journals-1
ObjectType-Correspondence-1
content type line 14
ObjectType-Article-2
ObjectType-Feature-1
ObjectType-Correspondence-3
content type line 23
ObjectType-Undefined-4
ISSN:1364-8535
1466-609X
1364-8535
1466-609X
1366-609X
DOI:10.1186/s13054-020-02896-5