Serum uric acid is associated with coronary artery calcification in early chronic kidney disease: a cross-sectional study

• Published in: BMC nephrology Vol. 22; no. 1; p. 247
• Main Authors: Han, Miyeun, Kim, Hyunsuk, Kim, Hyo Jin, Kang, Eunjeong, Kim, Yong-Soo, Choi, Kyu Hun, Kim, Soo Wan, Ahn, Curie, Oh, Kook-Hwan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.07.2021; BioMed Central; BMC
• Subjects: Adult; Aged; Arteriosclerosis; Atherosclerosis; Calcification; Calcification (ectopic); Calcium; Cardiovascular disease; Cardiovascular diseases; Cholesterol; Chronic kidney disease; Chronic kidney failure; Complications and side effects; Computed tomography; Coronary Angiography; Coronary artery; Coronary artery calcification; Coronary Artery Disease - blood; Coronary Artery Disease - complications; Coronary Artery Disease - diagnostic imaging; Coronary computed tomography; Coronary heart disease; Coronary vessels; Cross-Sectional Studies; Demographics; Diabetes; Disease Progression; Epidermal growth factor receptors; Female; Glomerular Filtration Rate; Health aspects; Humans; Hypertension; Kidney diseases; Laboratories; Lipids; Low density lipoprotein; Male; Medical screening; Middle Aged; Mortality; Multivariate analysis; Nephrology; Population; Proteins; Regression analysis; Renal Insufficiency, Chronic - blood; Renal Insufficiency, Chronic - complications; Renal Insufficiency, Chronic - physiopathology; Risk Factors; Statistical analysis; Tomography; Tomography, X-Ray Computed; Uric acid; Uric Acid - blood; Urine; Vascular Calcification - blood; Vascular Calcification - complications; Vascular Calcification - diagnostic imaging; South Korea; Coronary artery calcification; Chronic kidney disease; Uric acid; Coronary computed tomography
• ISSN: 1471-2369; 1471-2369
• DOI: 10.1186/s12882-021-02463-2

Although uric acid (UA) is regarded as a risk factor for cardiovascular disease, whether UA is an independent risk factor contributing to coronary artery calcification in chronic kidney disease (CKD) is not well known. We evaluated whether UA level is associated with coronary artery calcium (CAC) score in a predialysis CKD cohort. A total of 1,350 subjects who underwent coronary computed tomography as part of the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease were analysed. We conducted a logistic regression analysis to evaluate the association between UA and the presence of CAC. CAC was detected in 705 (52.2 %) patients, and the level of UA was significantly higher in CAC > 0 patients. UA showed a positive relationship with CAC > 0 in age- and sex-adjusted logistic regression analysis (Odds ratio (OR) 1.11, 95 % confidence interval (CI) 1.04-1.19, P = 0.003). However, UA showed no association with CAC > 0 in multivariate analysis. Further analysis showed that UA showed a positive association with CAC > 0 only in estimated glomerual filtration rate (eGFR) > 60 ml/min/1.73 m (OR 1.23, 95 % CI 1.02-1.49, P = 0.036) but not in eGFR 30-59 ml/min/1.73 m (OR 0.92, 95 % CI 0.78-1.08, P = 0.309) or < 30 ml/min/1.73 m (OR 0.92, 95 % CI 0.79-1.08, P = 0.426). UA level was significantly associated with CAC in early CKD, but not in advanced CKD.