Possible involvement of the autonomic nervous system in cervical muscles of patients with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS)

• Published in: BMC musculoskeletal disorders Vol. 22; no. 1; pp. 419 - 9
• Main Authors: Matsui, Takayoshi, Hara, Kazuhiro, Iwata, Makoto, Hojo, Shuntaro, Shitara, Nobuyuki, Endo, Yuzo, Fukuoka, Hideoki, Matsui, Masaki, Kawaguchi, Hiroshi
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05.05.2021; BioMed Central; BMC
• Subjects: Autonomic Nervous System; Cervical muscle; Chronic fatigue syndrome; Consent; Development and progression; Encephalomyelitis; Enrollments; Etiology; Fatigue; Fatigue Syndrome, Chronic - diagnosis; Fatigue Syndrome, Chronic - epidemiology; Fever; Headaches; Health aspects; Hospitalization; Humans; Muscles; Musculoskeletal diseases; Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS); Nausea; Neck; Nervous system; Nervous system, Autonomic; Pain; Patients; Physical therapy; Regression analysis; Risk factors; Subpopulations; Vertigo; Japan; Cervical muscle; Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS); Autonomic nervous system
• ISSN: 1471-2474; 1471-2474
• DOI: 10.1186/s12891-021-04293-7

Patients with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) sometimes present with stiffness of the cervical muscles. To investigate the pathophysiology of ME/CFS, this observational study compared patients with versus without recovery from ME/CFS through local modulation of the cervical muscles. Over a period of 11 years, a total of 1226 inpatients with ME/CFS who did not respond to outpatient care were enrolled in this study. All patients received daily cervical muscle physical therapy during hospitalization. Self-rated records documenting the presence or absence of ME/CFS, as well as the representative eight symptoms that frequently accompany it at admission and discharge, were compared. Pupil diameter was also measured to examine autonomic nervous system function involvement. The recovery rate of ME/CFS after local therapy was 55.5%, and did not differ significantly by sex, age strata, and hospitalization period. The recovery rates of the eight symptoms were variable (36.6-86.9%); however, those of ME/CFS in the symptom subpopulations were similar (52.3-55.8%). The recovery rates of all symptoms showed strong associations with that of ME/CFS (p < 0.001). The pupil diameter was more constricted in the ME/CFS-recovered patients than in the ME/CFS-unrecovered patients in the total population and the subpopulations stratified by sex, age, and hospitalization period. There was a strong association between the recovery of ME/CFS and other related whole-body symptoms. The recovery of ME/CFS may be partly linked to amelioration of the autonomic nervous system in the cervical muscles. UMIN000036634 . Registered 1 May 2019 - Retrospectively registered.