Crosstalk between N6-methyladenosine modification and circular RNAs: current understanding and future directions

• Published in: Molecular cancer Vol. 20; no. 1; pp. 121 - 12
• Main Authors: Wang, Xin, Ma, Rui, Zhang, Xilin, Cui, Lian, Ding, Yangfeng, Shi, Weimin, Guo, Chunyuan, Shi, Yuling
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 24.09.2021; BioMed Central; BMC
• Subjects: Adenosine - analogs & derivatives; Adenosine - metabolism; Circular RNA; Crosstalk; Cytoplasm; DNA methylation; Enzymes; Exports; Gene expression; Gene Expression Regulation; Humans; Localization; Metabolism; Methylation; MicroRNAs; Molecular biology; N6-methyladenosine; Physiological aspects; Physiology; Protein Biosynthesis; Review; RNA; RNA polymerase; RNA Splicing; RNA Stability; RNA Transport; RNA, Circular - genetics; RNA, Circular - metabolism; RNA-protein interactions; Transcription, Genetic; Circular RNA; Crosstalk; N6-methyladenosine
• ISSN: 1476-4598; 1476-4598
• DOI: 10.1186/s12943-021-01415-6

N -methyladenosine (m A) is a prevalent internal modification in eukaryotic RNAs regulated by the so-called "writers", "erasers", and "readers". m A has been demonstrated to exert critical molecular functions in modulating RNA maturation, localization, translation and metabolism, thus playing an essential role in cellular, developmental, and disease processes. Circular RNAs (circRNAs) are a class of non-coding RNAs with covalently closed single-stranded structures generated by back-splicing. CircRNAs also participate in physiological and pathological processes through unique mechanisms. Despite their discovery several years ago, m A and circRNAs has drawn increased research interest due to advances in molecular biology techniques these years. Recently, several scholars have investigated the crosstalk between m A and circRNAs. In this review, we provide an overview of the current knowledge of m A and circRNAs, as well as summarize the crosstalk between these molecules based on existing research. In addition, we present some suggestions for future research perspectives.