An overview: metal-based inhibitors of urease

• Published in: Journal of enzyme inhibition and medicinal chemistry Vol. 38; no. 1; pp. 361 - 375
• Main Authors: Yang, Wei, Peng, Zhiyun, Wang, Guangcheng
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.12.2023; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Ammonia; Bacteria; Carbon dioxide; Copper; Enzymes; Herbal medicine; Laboratories; Ligands; Metal ions; metal-based urease inhibitor; Metalloproteins; Metals; molecular docking; Molecular Docking Simulation; Nickel; Pharmaceutical sciences; Protons; Research Paper; Review; structure-activity relationship; Urease; Virulence; structure–activity relationship; Urease; molecular docking; Review; metal-based urease inhibitor
• ISSN: 1475-6366; 1475-6374; 1475-6374
• DOI: 10.1080/14756366.2022.2150182

Urease is a kind of nickel-dependent metalloenzyme, which exists in the biological world widely, and can catalyse the hydrolysis of urea into ammonia and carbon dioxide to provide a nitrogen source for organisms. Urease has important uses in agriculture and medicine because it can catalyse the production of ammonia. Therefore, in this review, metal-based inhibitors of urease will be summarised according to different transition metal ions. Including the urease inhibition, structure-activity relationship, and molecular docking. Importantly, among these reviewed effective urease inhibitors, most of copper metal complexes exhibited stronger urease inhibition with IC 50 values ranging from 0.46 μM to 41.1 μM. Significantly, the collected comprehensive information looks forward to providing rational guidance and effective strategies for the development of novel, potent, and safe metal-based urease inhibitors, which are better for practical applications in the future.