Quality of life of patients with metastatic pancreatic adenocarcinoma initiating first-line chemotherapy in routine practice

• Published in: BMC palliative care Vol. 19; no. 1; p. 103
• Main Authors: Laquente, Berta, Macarulla, Teresa, Bugés, Cristina, Martín, Marta, García, Carlos, Pericay, Carles, Merino, Sandra, Visa, Laura, Martín, Teresa, Pedraza, Manuela, Carnero, Beatriz, Guardeño, Raquel, Verdaguer, Helena, Mut, Alejandro, Vilanova, David, García, Adelaida
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 10.07.2020; BioMed Central; BMC
• Subjects: Adenocarcinoma; Adult; Aged; Cancer chemotherapy; Cancer metastasis; Cancer therapies; Care and treatment; Chemotherapy; Chi-Square Distribution; Clinical trials; Drug Therapy - methods; Drug Therapy - psychology; EORTC QLQ-C30; Female; Health-related quality of life; Humans; Male; Medical research; Metastasis; Middle Aged; Neoplasm Metastasis - diagnosis; Neutropenia; Pain; Palliative care; Pancreatic Cancer; Pancreatic Neoplasms - complications; Pancreatic Neoplasms - psychology; Performance status; Prospective Studies; Quality of life; Quality of Life - psychology; Sleep disorders; Surveys and Questionnaires; World health; Spain; Health-related quality of life; Cancer chemotherapy; Pancreatic Cancer; Performance status; EORTC QLQ-C30
• ISSN: 1472-684X; 1472-684X
• DOI: 10.1186/s12904-020-00610-4

Despite advances in surgery, radiotherapy, and chemotherapy, pancreatic adenocarcinoma often progresses rapidly and causes death. The physical decline of these patients is expected to impact their quality of life (QoL). Therefore, in addition to objective measures of effectiveness, the evaluation of health-related QoL should be considered a matter of major concern when assessing therapy outcomes. Observational, prospective, multicenter study including patients with metastatic pancreatic adenocarcinoma who started first-line chemotherapy in 12 Spanish centers. Treatment and clinical characteristics were recorded at baseline. Patients' health-related quality of life, ECOG, and Karnofsky index were measured at baseline, at Days 15 and 30, and every four weeks up to 6 months of chemotherapy. Health-related quality of life was measured using the EORTC-QLQ-C30 and EQ-5D questionnaires. Other endpoints included overall survival and progression-free survival. The study sample included 116 patients (median age of 65 years). Mean (SD) scores for the QLQ-C30 global health status scale showed a significant increasing trend throughout the treatment (p = 0.005). Patients with either a Karnofsky index of 70-80 or ECOG 2 showed greater improvement in the QLQ-C30 global health status score than the corresponding groups with better performance status (p ≤ 0.010). Pain, appetite, sleep disturbance, nausea, and constipation significantly improved throughout the treatment (p < 0.005). Patients with QLQ-C30 global health status scores ≥50 at baseline had significantly greater overall survival and progression-free survival (p = 0.005 and p = 0.021, respectively). No significant associations were observed regarding the EQ-5D score. Most metastatic pancreatic adenocarcinoma patients receiving first-line chemotherapy showed an increase in health-related quality of life scores throughout the treatment. Patients with lower performance status and health-related quality of life at baseline tended to greater improvement. The EORTC QLQ-C30 scale allowed us to measure the health-related quality of life of metastatic pancreatic adenocarcinoma patients receiving first-line chemotherapy.