American Indian chronic Renal insufficiency cohort study (AI-CRIC study)

• Published in: BMC nephrology Vol. 21; no. 1; pp. 291 - 11
• Main Authors: Unruh, Mark L, Arzhan, Soraya, Feldman, Harold I, Looker, Helen C, Nelson, Robert G, Faber, Thomas, Johnson, David, Son-Stone, Linda, Pankratz, Vernon S, Myaskovsky, Larissa, Shah, Vallabh O
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 22.07.2020; BioMed Central; BMC
• Subjects: AI-CRIC; American Indians; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - ethnology; Cardiovascular Diseases - physiopathology; Chronic kidney disease; Chronic kidney failure; Cohort analysis; Cohort Studies; Demographic aspects; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - ethnology; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - physiopathology; End stage Renal disease; Environmental exposure; Environmental factors; Health aspects; Health services; Humans; Indians, North American; Informed consent; Kidney diseases; Minority & ethnic groups; Mortality; Native Americans; Native languages; Native North Americans; Nephrology; Phenotyping; Renal insufficiency; Renal Insufficiency, Chronic - epidemiology; Renal Insufficiency, Chronic - ethnology; Renal Insufficiency, Chronic - metabolism; Renal Insufficiency, Chronic - physiopathology; Risk Factors; Southwestern United States - epidemiology; Statistics; Study Protocol; Southwestern United States; United States; United States > US; American Indians; eGFR; Environmental exposure; Cardiovascular disease; Chronic kidney disease; End stage Renal disease; Heart rate variability; AI-CRIC
• ISSN: 1471-2369; 1471-2369
• DOI: 10.1186/s12882-020-01954-y

Chronic kidney disease (CKD) is an increasing epidemic globally that is associated with adverse health outcomes including end stage kidney disease (ESKD), cardiovascular disease (CVD), and death. American Indians (AIs) have a higher prevalence of CKD than most other racial/ethnic groups, due in part to a high prevalence of type 2 diabetes. Other genetic and environmental factors not yet identified may also contribute to the disproportionate burden of CKD in AIs. We will establish 3 clinical centers to recruit AIs from the Southwest United States (US) to expand the Chronic Renal Insufficiency Cohort (CRIC) study. We will follow the current CRIC protocol for kidney and cardiovascular measures and outcomes, which include ambulatory monitoring of kidney function and the use of mobile health technologies for CVD sub-phenotyping, and compare the outcomes in AIs with those in other racial/ethnic groups in CRIC. AI-CRIC will identify the role of various risk factors for rapid loss of kidney function among AIs of the Southwest US. In addition, to better understand the natural history of CKD and CVD in this high-risk population, we will identify unique risk factors for CKD and CVD progression in AIs. We will also compare event rates and risk factors for kidney and cardiovascular events in AIs with the other populations represented in CRIC.